外周血C3,C4与慢性荨麻疹患者病情的相关性  

Investigate Chronic Urticaria Patient’s Condition Correlating to C3, C4 of Peripheral Blood

作　　者：何泽生[1] 安国芝[2] 赵海春[3] 

机构地区：[1]河北北方学院,河北张家口075000 [2]河北北方学院附属第一医院皮肤科,河北张家口075000 [3]河北北方学院附属第一医院检验科,河北张家口075000

出　　处：《中国皮肤性病学杂志》2013年第1期26-28,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨慢性荨麻疹(chronicurticaria,CU)患者外周血C3,C4水平与病情的相关性。方法采用免疫比浊法检测19例急性荨麻疹(acuteurticaria,AU)、146例CU患者的外周血C3,C4及IgG水平,并以20例健康人为对照。并通过荨麻疹活动评分(UAS)对165例荨麻疹患者的病情进行评分。结果 AU,CU患者外周血的C3,C4及IgG水平差异均无统计学意义(P均>0.05)。男女性CU患者外周血的C3,C4及IgG水平差异均无统计学意义(P均>0.05)。32例CU患者IgG水平高于正常值(IgG>17g/L),与C3,C4水平呈负相关(P<0.05)。UAS与荨麻疹外周血的C3,C4及IgG水平相关性差,差异无统计学意义(P均>0.05),但与IgG水平升高CU患者的C3,C4水平呈负相关,差异有统计学意义(P<0.05)。结论外周血C3,C4水平可以反应IgG水平升高的CU患者的病情。Objective To investigate the expression of C3, C4 and lgG in peripheral blood of patients with chronic urti- caria（CU） and its eorrelationship with CU patients＇ severity. Methods The expression of C3, C4 amt IgG was measured by Immune Turbidimetry in 19 patients with acute urticaria（AU） , 146 patients with CU and 20 normal controls. The severity of 165 patients with uriearia was evaluated by Urticaria Activity Score （UAS）. Results There were no statistically difference in the expression of C3, C4 and lgG between AU and CU patients （P 〉 0.05 ） , between male and female CU patients respectively（ P 〉 0.05 ）. The expression of IgG was higher than normal control（ IgG 〉 17g/L） in 32 CU patients, and showed negative correlation with the expression of C3 and C4 （P 〈 0.05 ）. UAS was poor relation to the expression of C3, C4 and IgG in urticaria patient＇s peripheral blood, but was negative con＇elation to the levels of C3, C4 in CU patients whose expression of lgG was higher than normal control（ P 〈 0.05 ）. Conclusion The expression of C3, C4 could respond to the severity of CU patients whose expression of IgG is higher than normal control.

关 键 词：慢性荨麻疹(CU) C3 C4 荨麻疹活动评分(UAS) 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]