亚急性皮肤型红斑狼疮合并甲亢1例  

A Case of Subacute Cutaneous Lupus Erythematosus Associated with Hyperthyroidism

作　　者：张娟[1] 李东霞[1] 

机构地区：[1]内蒙古医科大学附属医院皮肤科,内蒙古呼和浩特市010050

出　　处：《中国皮肤性病学杂志》2013年第1期76-77,共2页The Chinese Journal of Dermatovenereology

摘　　要：患者女,35岁。全身红色皮疹伴发热2个月,上半身皮疹加重20d。查体:面颈部及双上肢环状红斑,双手震颤,突眼,甲状腺肿大;ANA1∶160,SSA3(+);T4,FT4↑,TSH↓,TG-Ab,TPO-Ab↑;甲状腺彩超示:甲状腺弥漫性肿大,血流丰富。皮损组织病理示:表皮变薄,基底液化变性,真皮浅层血管及附属器周围局灶性淋巴细胞为主的炎细胞浸润,可见个别噬黑素细胞,胶原轻度嗜碱变性。诊断:SCLE合并甲亢。SCLE合并甲亢尚未见报道,可能与两者有相同的遗传及免疫学基础有关。A 35-year-old female patient admitted to the hospital complaining of generalized skin rash with erythema- tous macules for 2 months, aggravate rashes on upper body for 20 ddys. Physical examination showed that erythema annulare appeared on face, neck and both upper limbs, tremor of the hands, exophthalmos, thyroid gland enlargement; ANA 1 ： 160; SSA 3 ＋, thyroid function revealed that T4, FT4 ↑ , TSH ↓ , TG-Ab, TPO-Ab ↑ ; Ultrasound showed that diffuse enlargement of the thyroid and rich blood flow ; Histopathology of the chest skin lesion showed that epidermal thinning, liquefaction degeneration of basal layers, in superfi- cial layer of dermis, perivascuar and periadnexal inflammatory cells infiltration, primarily lymphocyte, visi- ble individual melanocytes, basophilic degeneration of collagen fibers. Diagnosis ： Subacute cutaneous lupus erythematosus associated with hyperthyroidism. It has not been reported, maybe they have the same genetic and immune bases.

关 键 词：亚急性皮肤型红斑狼疮 甲亢 自身免疫性疾病 

分 类 号：R593.24[医药卫生—内科学] R581.1[医药卫生—临床医学]