Molecular logic computing model based on DNA self-assembly strand branch migration  

作　　者：ZHANG Cheng MA LiNa DONG YaFei YANG Jing XU Jin 

机构地区：[1]Institute of Software,School of Electronics Engineering and Computer Science,Key Laboratory of High Confidence Software Technologies of Ministry of Education,Peking University [2]College of Life Science,Shaanxi Normal University [3]School of Control and Computer Engineering,North China Electric Power University

出　　处：《Chinese Science Bulletin》2013年第1期32-38,共7页

基　　金：supported by the National Natural Science Foundation of China (61127005,61133010,61033003,60910002 and 61143003);Ph.D.Programs Foundation of the Ministry of Education of China (20110001130016);the Postdoctoral Special and Normal Science Foundation of China(201104018,20100480128,2011M500197)

摘　　要：In this study,the DNA logic computing model is established based on the methods of DNA self-assembly and strand branch migration.By adding the signal strands,the preprogrammed signals are released with the disintegrating of initial assembly structures.Then,the computing results are able to be detected by gel electrophoresis.The whole process is controlled automatically and parallely,even triggered by the mixture of input signals.In addition,the conception of single polar and bipolar is introduced into system designing,which leads to synchronization and modularization.Recognizing the specific signal DNA strands,the computing model gives all correct results by gel experiment.In this study, the DNA logic computing model is established based on the methods of DNA self-assembly and strand branch migration. By adding the signal strands, the preprogrammed signals are released with the disintegrating of initial assembly structures Then, the computing results are able to be detected by gel electrophoresis. The whole process is controlled automatically and parallely, even triggered by the mixture of input signals. In addition, the conception of single polar and bipolar is introduced into system designing, which leads to synchronization and modularization. Recognizing the specific signal DNA strands, the computing model gives all correct results by gel experiment.

关 键 词：DNA链 运算模型 自组装 逻辑 迁移 输入信号 分子 凝胶电泳 

分 类 号：Q523[生物学—生物化学]