雾化吸入PS在正常和内毒素性肺损伤兔肺内吸入量及分布  

INSPIRATORY DOSES AND DISTRIBUTIONS OF EXOGENOUS PULMONARY SURFACTANT IN NORMAL AND DAMAGED LUNG INDUCED BY ENDOTOXIN IN RABBITS WITH NEBULIZING

作　　者：兰和魁[1] 封志纯[1] 李秀云 彭武和 赵宏[1] 杨丽华[1] 

机构地区：[1]第一军医大学附属珠江医院儿科,广州510282 [2]广州赤岗一七七医院 [3]南方医院核医学科,广州510515

出　　处：《中国应用生理学杂志》2000年第1期64-67,共4页Chinese Journal of Applied Physiology

摘　　要：目的 :超声雾化吸入肺表面活性物质 (PS)治疗兔急性肺损伤时 ,观察PS肺内吸入量及分布。方法 :大肠杆菌内毒素致兔急性肺损伤后 ,采用99m　Tc DTPA和PS混合进行雾化吸入治疗 ,测定SP吸入肺内百分比及各种肺野所占比例。结果 :兔急性肺损伤经超声雾化吸入治疗吸入肺内量 (以磷脂计 )正常组、气管插管雾化组、口罩雾化组分别为 5 .34、7.0 1、5 .6 1mg/kg体重 ,上、中、下肺野极差分别为 6 .6、1 9.5、1 0 .4% ,内、中、外带极差分别为 1 6 .5 %、2 0 .9%、1 3.8%。结论 :两种治疗方法均能达到治疗量 ,面罩吸入分布更均匀。Aim: Acute lung injury (ALI) of rabbits was treated by nebulizing exogenous surfactant (PS) to observe inspiratory dose and distribution of PS. Methods:After ALI was induced by endotoxin of E.coli,mixture of 99m Tc DTPA and PS was nebulized. Inhaling percentage and proportion of PS of various areas in pulmonary parenchyma were determined. Results:Inhaling phosphatide doses in three groups (normal,intubation,mask) were 5.34,7.01,5. 61 mg/Kg wt respectively.The range of each group was 6. 6%, 19. 55 ,10.4% between the most and the least in different area and 16. 5%,20. 9%,13. 8% in inner and outer zones respectively.Conclusion:The phospholipid inspired were more than the effective dose in two groups. More quantities were inhaled when using intubation ( P <0.05). The uniformity of mask inhalation is better than that of intubation ( P <0.01).

关 键 词：超声雾化吸入 急性肺损伤 ET PS NRDS ARDS 分布 

分 类 号：R563.05[医药卫生—呼吸系统]