不同负荷运动对急性心理应激大鼠Th1/Th2平衡的影响  

The effect of different loads of exercise on Th1/Th2 balance in SD rats after acute mental stress

作　　者：徐唯[1] 

机构地区：[1]盐城师范学院体育学院,江苏盐城224002

出　　处：《现代预防医学》2013年第2期333-335,共3页Modern Preventive Medicine

摘　　要：目的研究不同负荷运动对急性心理应激大鼠外周血T辅助细胞(Th)Th1/Th2平衡的影响(通过IFN-γ/IL-4的比值)。方法 8周龄SD大鼠56只,随机分为7组。进行12周的游泳训练,最后施加一次15min的心理应激,并在心理应激后1h内测定血清Th1型(γ干扰素、IFN-γ)和Th2型(白介素4、IL-4)细胞因子的含量,最后比较IFN-γ/IL-4的比值。结果 (1)与对照组相比,心理应激组大鼠血清IFN-γ/IL-4比值明显升高(P﹤0.05);(2)与心理应激组相比,应激+运动组大鼠血清IFN-γ/IL-4比值都升高,其中应激+60min运动组显著高于应激组(P﹤0.01)。结论急性心理应激显著影响了大鼠的Th1/Th2平衡,使大鼠Th1/Th2细胞功能由Th2向Th1偏移,提高了大鼠的细胞免疫功能;中小负荷运动可以进一步促进这种偏移作用,中等负荷的运动与小负荷的运动相比效果更显著。OBJECTIVE To study the effect of different loads of exercise on blood serum Th1/Th2 balance （by IFN-γ/IL-4 ratio） in SD rats after acute mental stress. METHODS 56 rats were divided into 7 groups randondy.The rats were carried through a swimming training of 12 weeks and exerted on a 15 minutes acute mental stress in the last and the level of Th1 cytokine （IFN-γ） and Th2 cytokine （IL-4） were measured within one hour and then the ratios of IFN-γ/IL-4 were compared. RESULTS （1） Compared with the control group, the ratio of IFN-γ/IL-4 in mental stress group rose significantly （P 〈 0.05 ）. （2） Compared with mental stress group; both ratios of IFN-γ/IL-4 in stress ＋ exercise groups were hoisted, tbereinto, the ratio of IFN-γ/IL-4 in stress ＋60minites exercise group was higher significantly than that in mental stress group （P 〈 0.01 ）. CONCLUSION Th1/Th2 balance in SD rats is affected significantly by actual mental stress.h makes the Th1/Th2 cell function to deviate from Th2 to Th1 and this enhances cell immune function of SD rats.The low and moderate exercise can promote further this kind of deviation. Furthermore, the effect of moderate exercise is better than that of low exercise.

关 键 词：急性心理应激 干扰素-γ 白细胞介素4 TH1 Th2平衡 

分 类 号：R395[哲学宗教—心理学]