氯胺酮丙泊酚合剂在人工流产术中的麻醉效果观察  

Observation on efficacy of ketofol for abortion procedures

作　　者：张新敏[1] 马驰[2] 庞磊[1] 麻海春[1] 

机构地区：[1]吉林大学第一医院麻醉科,吉林长春130021 [2]吉林大学白求恩医学院

出　　处：《中国妇幼保健》2013年第2期332-335,共4页Maternal and Child Health Care of China

基　　金：吉林省科技厅国际合作项目〔20110759〕

摘　　要：目的:观察在人工流产术中用不同浓度氯胺酮丙泊酚合剂麻醉效果,并与丙泊酚-芬太尼或单独使用丙泊酚麻醉效果进行比较。方法:选取100例18～40岁流产术患者,随机分为:K21,K31,K41,PF及P组,K21,K31,K41组分别以丙泊酚、氯胺酮按2:1,3∶1及4∶1比例配制成氯胺酮丙泊酚合剂,PF组为丙泊酚芬太尼组,P组为丙泊酚组,比较不同组间麻醉效果。结果:K21组的镇静、恢复及出室时间较其他组长(P<0.05)。所有氯胺酮丙泊酚合剂组术后眩晕发生率高,PF组及P组术中呼吸抑制发生率高(P<0.05)。氯胺酮丙泊酚合剂组较其他组丙泊酚的使用量减少,而P组丙泊酚的使用量最大(P<0.05)。结论:在流产术中,按3∶1或4∶1比例配制的氯胺酮丙泊酚合剂能达到良好麻醉效果,术中不良反应发生率低。Objective： To compare the anesthesia effectiveness of different proportions of ketamine and propofol in ketofol, and ketofol with propofol -fentanyl and propofol alone in abortion procedures. Methods： A total of 100 patients who were abortion and aged 18 - 40 were randomly divided into 5 groups. K21, K31 and K41 group were given ketofol in the ratios of propofol： ketamine 2： 1, 3：1 and 4： 1 respectively intravenously in small aliquots ; PF group was given propofol 1.5 - 2 mg/kg and fentanyl 1 mcg/kg whereas P group was given only propofol 2 mg/kg or according to the anesthesiologistg discretion. Results： The times of sedation, recovery and discharge in K21 group were longer than the other groups （P 〈0.05 ） . The incidence of postoperative dizziness were high in all ketofol groups, whereas the inci- dence of intraoperative respiratory depression in PF group and P group （ P 〈 0. 05 ） . Ketofol groups required less dosage of propofol com- pared with the non - ketofol groups and P group required the highest dosage of propofol （P 〈 0. 05） . Conclusion ： Ketofol is as effective as propofol -fentanyl combination especially in the ratios 3：1 and 4：1 （propofol： ketamine） for abortion procedures.

关 键 词：氯胺酮丙泊酚合剂 氯胺酮 丙泊酚 芬太尼 流产 

分 类 号：R714.21[医药卫生—妇产科学]