苯乙胺衍生的手性膦-亚磷酰胺酯配体在Rh-催化α-烯醇酯膦酸酯的不对称氢化反应中的应用  

Rh-Catalyzed Asymmetric Hydrogenation of α-Enol Ester Phosphonates with 1-Phenylethylamine-Derived Phosphine-Phosphoramidite Ligands

作　　者：胡娟[1] 王道永[1] 郑卓[1] 胡向平 

机构地区：[1]中国科学院大连化学物理研究所,辽宁大连116023

出　　处：《分子催化》2012年第6期487-492,共6页Journal of Molecular Catalysis(China)

基　　金：国家自然科学基金(No.20972156)

摘　　要：将苯乙胺衍生的手性膦-亚磷酰胺酯配体应用在Rh-催化α-烯醇酯膦酸酯的不对称氢化反应中,考察了配体结构及反应条件对反应结果的影响,并在优化的条件下研究了各种底物的适用范围,产物的对映选择性最高>99%ee.A series of phosphine-phosphoramidite ligands derived from commercially available,inexpensive chiral 1-phenylethylamine were employed in the Rh-catalyzed asymmetric hydrogenation of various α-enol ester phosphonates.The results indicated that the ligand（Sc,Sa）-2b bearing a Me-group on amino moiety exhibited similar enantioselectivity but superior catalytic activity to（Rc,Ra）-THNAPhos.Excellent enantioselectivities（up to 99% ee） and high catalytic activity（S/C up to 5 000） have been achieved in the hydrogenation of various β-alkyl and β-aryl substituted substrates,demonstrating the high potential of this phosphine-phosphoramidite ligand in the preparation of optically active α-hydroxyphosphonates

关 键 词：不对称催化 铑 膦-亚磷酰胺酯配体 α-烯醇酯膦酸酯 氢化 

分 类 号：O643.32[理学—物理化学]