向量评估遗传算法优化珍珠菜抗肿瘤有效成分的研究  

Optimization of Vector Evaluated Genetic Algorithm Study on Extraction Technology of Active Ingredients for Anti-tumor in Lysimachia Clethroides Duby

作　　者：徐彦杰[1] 刘晓红[1] 杨晓文[1] 陈益[2] 仇丽霞[1] 

机构地区：[1]山西医科大学公共卫生学院卫生统计学教研室,030001 [2]电子科技大学机电学院,610054

出　　处：《中国卫生统计》2012年第6期815-818,共4页Chinese Journal of Health Statistics

基　　金：国家自然科学基金资助项目(30872183);山西省自然科学基金资助项(2007011087)

摘　　要：目的研究向量评估遗传算法(VEGA)在珍珠菜抗肿瘤有效成分提取工艺条件中的应用,并对其效果进行评价。方法对珍珠菜抗肿瘤有效成分提取工艺正交设计试验数据建立以总黄酮含量和总皂苷含量的子目标模型,采用VEGA对其进行多目标优化,搜索最优提取条件。利用课题组成员电子科技大学软件工程师陈益提供的Matlab2009a外挂SGALAB工具箱beta5008完成遗传算法的寻优;利用SPSS13.0软件进行统计分析。结果得到的最优工艺条件为80%乙醇,8倍用量,提取1次,提取时间根据实际情况选择的条件下的搜索总黄酮含量为10.36%、总皂苷含量25.79%。结论 VEGA收索的Pareto非劣解在保证多目标都最优的前提下是比较理想的,为珍珠菜抗肿瘤有效成分的最优条件选择提供了合理的方法,可推广到其他药物的最优条件选择。Objective To study the application of optimization analysis of Vector Evaluated Genetic Algorithm（VEGA）on extraction technology of active ingredients for Anti-tumor in Lysimachia clethroides Duby.Methods To establish sub-target model of total flavonoids and total Saponin on extraction technology of active ingredients for Anti-tumor in Lysimachia clethroides Duby experimental data in orthogonal design.Applying VEGA explores the optimal extracting conditions and compare results with Single-objective genetic algorithm.Using SGALAB beta5008 of the Matlab2009a plug-in tool-box,which was written by Chen Yi in the University of Electronic Science and Technology,achieves the genetic algorithm optimization;SPSS13.0 software was used for statistical analysis.Results The optimal conditions for the ethanol concentration 80%,8 times of ethanol dosage,extraction times is 1,extracting time according to the actual situation.Under these conditions,the results of the total flavonoids is 10.36%,the total Saponin is 25.79%.Conclusion VEGA provides a reasonable pareto ensuring the optimal multi-objective,which provides a reasonable method of choice for the active ingredients for Anti-tumor in Lysimachia clethroides Duby.This method can be extended to the selection of other drugs.

关 键 词：珍珠菜 正交试验 遗传算法 多目标优化 Pareto非劣解 

分 类 号：R284.1[医药卫生—中药学]