肺形草化学成分研究  

Chemical Constituents of Tripterospermum chinense

作　　者：张涛[1,2] 李彬[2] 陈立[2] 刘士军[2] 董俊兴[2] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124 [2]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《军事医学》2012年第12期920-924,共5页Military Medical Sciences

摘　　要：目的对中草药肺形草60%乙醇提取物进行化学成分研究。方法采用硅胶柱色谱,Sephadex LH-20凝胶柱色谱,反相C18柱色谱和重结晶等方法进行分离纯化,通过波谱解析和理化鉴别进行结构鉴定。结果分离鉴定了13个化合物,包括9个黄酮类,3个三萜类,1个酚酸类,它们分别为异牡荆素(1),异牡荆素-7-O-鼠李糖(2),异荭草素-7-O-鼠李糖(3),肥皂草苷(4),三叶豆苷-2″-O-鼠李糖(5),三叶豆苷(6),8-羟基-1,2,6-三甲氧基呫吨酮(7),1,7-二羟基-3,8-二甲氧基呫吨酮(8),1,2,8-三羟基-5,6-二甲氧基呫吨酮(9),齐墩果酸(10),熊果酸(11),胡萝卜苷(12),咖啡酸(13)。结论化合物2～6为首次从该属植物中分离得到;化合物1,10～12为首次从该植物中分离得到。首次报道了化合物2和3的核磁共振数据。Objective To investigate the chemical constituents of 60% EtOH extract of Tripterospermum chinense. Methods The compounds were isolated by column chromatography over silica gel, Sephadex LH-20, RP-Cls silica gel, and recrystallization. Structures of the compounds were elucidated physicochemical properties and spectral data. Results Thirteen compounds were isolated and identified as isovitexin （1）, 7-O-rhamnopyransoyl-isovitexin （2）, 7-O-rhamnopyr- ansoyl-isoorientin （3）, saponarin （4）, 2-O-rhamnopyransoyl-trifoliside （5）, trifoliside （6）, 8-hydroxy-1, 2, 6-trime- thoxyxanthone （7）, 1, 7-dihydroxy-3, 8-dimethoxyxanthone （8）, 1, 2, 8-trihydroxy-5, 6-dimethoxyxanthone （9）, oleanolic acid （10）, ursolic acid （11）, daucosterol （12）, and caffeic acid （13）. Conclusion Compounds 2 -6 were isolated from Tripterospermum for the first time. Compounds 1, and 10 - 12 were isolated from this plant for the first time. The NMR data of compounds 2 and 3 were reported for the first time.

关 键 词：肺形草 化学成分 核磁共振 

分 类 号：R284[医药卫生—中药学]