氟氯氰菊酯亚急性吸入毒性实验研究  

Inhalation toxicity of cyfluthrin for 28-day repeated dose in rats

作　　者：秦珩[1] 乔善磊[1] 顾军[1] 钟义红[1] 杨洪宝[1] 王玉邦 施爱民[1] 

机构地区：[1]南京医科大学公共卫生学院,江苏省医药农药兽药安全性评价与研究中心,南京210029

出　　处：《军事医学》2012年第12期925-928,共4页Military Medical Sciences

基　　金：江苏高校优势学科建设工程资助项目

摘　　要：目的观察氟氯氰菊酯染毒大鼠亚急性吸入毒性。方法 7周龄清洁级SD大鼠随机分成5组,每组雌雄各5只,分别吸入氟氯氰菊酯0,7.81,9.05,18.98 mg/m3及溶剂二甲亚砜,每天6 h,每周5 d,共28 d。实验结束时取血液做常规生化指标、血细胞指标、血凝学指标检测。取心、肝、脾等8种主要脏器称重并做病理组织学检查。结果 18.98 mg/m3组动物在染毒中呈现反复抓挠口周、烦躁不安、鼻有血性分泌物、颤抖,染毒结束后呈现萎靡、蜂腰、四肢无力的体征。雌性动物的毒性表现较雄性低。与溶剂对照组相比,雄性大鼠体质量及总食饲效率降低、肾质量下降、肾上腺脏器系数升高;生化检查显示,雌雄动物天冬氨酸转氨酶(AST)升高。9.05 mg/m3组雄性动物有同样指标变化。其他剂量组动物未见明显异常表现。病理组织学观察均未见明显异常病变。结论氟氯氰菊酯染毒大鼠亚急性吸入后未观察到有害作用水平(NOAEL)为7.81 mg/m3,具有一定的神经毒性。Objective To determine the inhalation toxicity and find the non-observed adverse effect level （NOAEL） of cyfluthrin for a 28-day repeated dose in rats. Methods Clean-grade SD rats were randomly divided into 5 groups with 5 fe- males and 5 males in each. The animals inhaled DMSO or cyfluthrin at the concentration of 0, 7. 81, 9. 05 and 18.98 mg/m3 for 4 weeks （6 h/d, 5 d/w）. At the end of inhalation, all the animals were kindly sacrificed. Their organs were collected for histopathological examination. Blood samples were collected for analysis of complete blood count, bio- chemistry and coagulation. Results The animals in 18.98 mg/m3 group were found scratching repeatedly around the mouth, listless, fidgeting, trembling, discharging blood around the mouth and nose. However, symptoms in females were less serious than in males. Furthermore, the body mass, feed efficiency, weight of kidney of animals in this dose male group were found decreased compared with the control group. Biochemistry detection revealed that serum AST was elevated markedly in both genders of 18.98 mg/m3 group and in males of 9.05 mg/m3 group, No obvious abnormity was found in 7.81 mg/m3 group or control group. Conclusion Based on the results above, the non-observed adverse effect level （NOAEL） of cyfluthrin in SD rats is 7.81 mg/m3 for 28 d repeated inhalation in this study.

关 键 词：氟氯氰菊酯 拟除虫菊酯 吸入 中毒 

分 类 号：R114[医药卫生—卫生毒理学]