骨溶解实验陶瓷磨损微粒的制备  

Preparation of ceramic wearing particles to study osteolysis

作　　者：孙国静[1] 赵建宁[1] 郭亭[1] 薛孝威[1] 樊根涛[1] 胡波[1] 邓亚玲[2] 姜海晨[2] 

机构地区：[1]第二军医大学南京临床医学院南京军区南京总医院骨科,南京210002 [2]南京理工大学材料科学与工程学院,南京210094

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2012年第4期276-280,共5页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：南京市科技发展计划项目(2012sc311020)

摘　　要：目的探索制备第3代陶瓷股骨头假体陶瓷微粒方法,为人工关节假体无菌性松动和陶瓷微粒对组织相容性研究提供材料。方法取1枚第3代陶瓷股骨头假体部件,制成不规则碎块状,通过球磨法和无水乙醇重力液力分级法制成人工关节陶瓷微粒,分析微粒元素和粒度,用扫描电镜观察陶瓷微粒表征。结果元素分析在球磨过程无杂质污染。处理后90%陶瓷微粒直径<3.19μm,符合医学实验研究的要求。结论本研究使用的方法可以产生大量陶瓷微粒,可以为人工关节陶瓷材料体内外研究提供微粒来源。Objective To explore the preparation of the ceramic particles of the third-generation ceramic femo- ral head prosthesis for the study of the mechanism of aseptic loosening and evaluate its histocnmpatibility. Methods A third-generation ceramic femoral head component was knocked into irregular broken blocks, ceramic particles were made by ball milling and ethanol gravity hydraulic classification. Particle size, size distribution, chemical composition and shape were characterized by element trace analysis, laser countersizer, and scanning electron microscopy. Results Ceramic particles were pure without impurity by elemental analysis in the milling process. Diameter of the ceramic particles were smaller than 3.19 μm in 90% of total particles, in line with the the required diameter of medical experiments. Conclusion This method can produce a large number of ceramic particles, which provide a large number of particle sources to explore mechanism of osteolysis.

关 键 词：骨溶解 陶瓷磨损微粒 人工关节 

分 类 号：R683[医药卫生—骨科学]