骨质量与骨质疏松性骨折  

Bone quality and osteoporotic fracture

作　　者：黄淑纾[1] 林华[1] 朱秀芬[1] 陈新[1] 刘畅畅[1] 

机构地区：[1]南京大学医学院附属鼓楼医院骨病中心,南京210008

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2012年第4期285-291,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：江苏省社会发展基金(BE2011605)

摘　　要：骨质疏松症是一种以骨量低下和骨微结构破坏导致骨脆性增加,易发骨折为特征的疾病。骨质疏松的主要合并症——骨折是骨强度降低的结果。骨强度取决于骨骼的矿物质含量和质量。双能X线骨密度测量仪(DXA)测出的骨密度(BMD)是骨质疏松症的诊断标准,可反映骨矿物质含量。其他一些影响骨强度的特性被称为骨质量。骨质量包括骨重建(骨转换)、骨几何学、骨微结构、骨基质、骨矿化、骨胶原、骨微损伤及其修复等。骨质量从以上各个方面影响骨质疏松性骨折。本综述旨在更新骨质量的相关内容,包括骨质量与生物力学的关系及其如何影响骨质疏松性骨折。Osteoporosis is a disease defined by decreased bone mass and alteration of microarchitecture which results in increased bone fragility and increased risk of fracture. The major complication of osteoporosis, i. e. , fracture, is due to a lower bone strength. Bone strength depends not only on the quantity of bone mineral but also on the bone quality. Bone mineral density （BMD） measured by dual-energy X-ray absorptiometry （DXA） which is used for osteoporosis diagnosis, reflects the quantity of bone mineral. Several other bone properties that influence bone strength have been defined as ＂bone quality＂. Bone quality includes bone remodeling （bone turnover）, bone geometry, bone microstructure, bone matrix, bone mineralization, bone collagen, bone microdamage and its repair. Studies have shown that bone quality influences osteoporetic fractures from these above aspects. This review aims to update the concepts about bone quality, its relationship with biomechanics and how it influences osteoporotic fracture.

关 键 词：骨质疏松性骨折 骨质量 骨强度 骨密度 

分 类 号：R681[医药卫生—骨科学]