E-选择素和细胞间黏附分子-1检测与急性冠状动脉综合征的相关性  

Discussion of the relationship between E-selectin and ICAM-1with acute coronary syndrome

作　　者：唐甜甜[1] 王宝权[2] 张蕴莉[1] 

机构地区：[1]辽宁医学院附属第一医院检验科,辽宁锦州121001 [2]辽宁医学院附属第一医院重证医学科,辽宁锦州121001

出　　处：《中国现代医学杂志》2012年第30期99-101,共3页China Journal of Modern Medicine

基　　金：辽宁省自然科学资助项目(No:20092185);辽宁省教育厅资助项目(No:L2010293)

摘　　要：目的探讨E-选择素(E-selectin)和细胞间黏附分子-1(ICAM-1)检测在急性冠状动脉综合征(ACS)发展中的作用。方法将197例住院患者分成三组:稳定性心绞痛组(SAP)(n=62)、急性冠状动脉综合征(n=90)、对照组(n=45)。采用酶联免疫吸附试验E-selectin和ICAM-1的血清学变化进行分析。结果ACS组的E-selectin和ICAM-1的血清学水平显著高于其它两组,差异有显著性(P<0.01),ICAM-1的血清学水平在SAP组和对照组中,差异有显著性(P<0.01)。E-selectin和ICAM-1的血清学水平呈正相关性。结论E-selectin和ICAM-1联合检测对诊断急性冠状动脉综合征的病变程度具有重要临床意义。【Objective】To explore the difference of E-selectin and intercellular adhesion molecule-1（ICAM-1） in different type of acute coronary syndrome（ACS） and the associated correlations between E-selectin and ICAM1with ACS.【Methods】197 patients who were divided into three groups： stable effort angina group（SAP）（n =62）,acute coronary syndrome group（ACS）（n =90）,control group（n =45）.The serum levels of E-selectin and ICAM-1 were detected by ELISA,and the relationship between E-selectin and ICAM-1 were analyzed.【Results】The serum levels of E-selectin and ICAM-1 in ACS group were significantly higher than those in SAP and control group（P 0.01）,and the serum levels of ICAM-1 between SAP and control group were different（P 0.01）.There was positive correlation between E-selectin and ICAM-1 in ACS（P〈0.05）.【Conclusion】The serum levels of E-selectin and ICAM-1 are important index for the diagnosis of ACS and the severity of ACS.

关 键 词：E-选择素 细胞间黏附分子-1 急性冠状动脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病]