介孔二氧化硅纳米粒传递肿瘤诊疗药物的研究进展  

Mesoporous silica nanoparticles for cancer theranostic drug delivery

作　　者：王昕[1] 滕兆刚[1] 黄小银[2] 卢光明[1] 

机构地区：[1]南京军区南京总医院医学影像科,江苏南京210002 [2]南京军区南京总医院肿瘤科,江苏南京210002

出　　处：《药学学报》2013年第1期8-13,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金国际合作与交流项目(81120108013);国家重点基础研究发展计划(2011CB707700);国家自然科学基金重点项目(30930028)

摘　　要：介孔二氧化硅纳米粒(mesoporous silica nanoparticles,MSNs)作为药物载体应用于生物医药领域已成为纳米药剂研究的热点。本文针对在肿瘤诊疗领域的MSNs最新实验设计,重点讨论MSNs载药系统在控制性释放、靶向性输送和克服多药耐药的应用策略。MSNs为肿瘤诊疗药物的传递提供良好的运载平台,具有极大的发展潜力和独特优势。Mesoporous silica nanoparticles as drug carrier have become the new hot point in the field of biomedical application in recent years.This review focuses on the more recent developments and achievements on experimental design aspect of mesoporous silica nanoparticles with cancer diagnosis and therapy.The key advances of functionalization strategies of mesoporous silica nanoparticles with controlled release,tumor targeting and overcoming multidrug resistance are discussed in particular.Mesoporous silica nanoparticles as unique delivery systems have the potential to provide significantly a sound platform for cancer theranostic application.

关 键 词：二氧化硅 纳米粒 药物载体 肿瘤 

分 类 号：R943[医药卫生—药剂学]