海洋来源真菌Ascotricha sp.ZJ-M-5中一个新的3,4-裂环羊毛脂烷型三萜  

A new 3, 4-seco-lanostane triterpenoid from a marine-derived fungus Ascotricha sp. ZJ-M-5

作　　者：谢磊睿[1,2] 李丹毅[2] 王培乐[1,2] 华会明[1,2] 武昕[3] 李占林[1,2] 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 [2]沈阳药科大学中药学院,辽宁沈阳110016 [3]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016

出　　处：《药学学报》2013年第1期89-93,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(20872094)

摘　　要：为了研究海洋来源真菌Ascotricha sp.ZJ-M-5的次级代谢产物,采用大孔吸附树脂、硅胶、ODS开放柱以及Sephadex LH-20等柱色谱方法进行分离,得到10个化合物,根据理化性质及其波谱数据鉴定了化合物的结构,分别为刺囊壳酸B(1)、(3R)-6-hydroxymellein(2)、β-carboline(3)、(22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol(4)、(22E,24R)-ergosta-7,22-diene-3β,5α,6β,9α-tetraol(5)、cyclo(Leu-Pro)(6)、cyclo(Ile-Leu)(7)、cyclo(Pro-Val)(8)、cyclo(Pro-Gly)(9)和cyclo(Hpro-Ala)(10)。其中化合物1为首次从丝状真菌中分离得到的新的3,4-裂环羊毛脂烷型三萜类化合物,化合物2～10为首次从刺囊壳属(Ascotricha)真菌中分离得到。To study the secondary metabolites of a marine-derived fungus Ascotricha sp.ZJ-M-5,several chromatographic methods including macroporous resin,silica gel,ODS and Sephadex LH-20 were used to isolate the compounds,and their structures were elucidated on the basis of physicochemical properties and spectroscopic methods.Ten compounds were obtained and identified as ascotrichic acid B（1）,（3R）-6-hydroxymellein（2）,β-carboline（3）,（22E,24R）-ergosta-7,22-diene-3β,5α,6β-triol（4）,（22E,24R）-ergosta-7,22-diene-3β,5α,6β,9α-tetraol（5）,cyclo（Leu-Pro）（6）,cyclo（Ile-Leu）（7）,cyclo（Pro-Val）（8）,cyclo（Pro-Gly）（9）,and cyclo（Hpro-Ala）（10）.Among them,compound 1 is a new 3,4-seco-lanostane triterpenoid which has been isolated from the filamentous fungi for the first time,and compounds 2 10 are firstly isolated from Ascotricha genus.

关 键 词：刺囊壳属 次级代谢产物 三萜 3 4-裂环羊毛脂烷 刺囊壳酸B 

分 类 号：R936[医药卫生—生药学]