依普利酮与氯沙坦对轻中度高血压病患者动脉僵硬度及胰岛素生长因子-1的影响  

Effect of eplerenone and losartan on arterial stiffness and insulin-like growth factor 1 in patients with mild to moderate essential hypertension

作　　者：黄荣杰[1] 刘唐威[1] 郭玉冰[1] 郑云香[1] 

机构地区：[1]广西医科大学第一附属医院高血压病区,南宁530021

出　　处：《临床心血管病杂志》2013年第1期64-67,共4页Journal of Clinical Cardiology

摘　　要：目的:探讨依普利酮与氯沙坦对轻中度原发性高血压患者动脉僵硬度及胰岛素生长因子-1(IGF-1)的影响。方法:将84例轻中度原发性高血压患者分为依普利酮组和氯沙坦组(各42例),分别口服依普利酮50mg或氯沙坦50mg每天1次,每2周复诊1次,治疗前及治疗后12周进行肝肾功能、电解质、血糖、血脂、血常规、尿常规、动态血压监测、臂-踝脉搏波传导速度(baPWV)和血浆IGF-1的测定。结果:两组治疗12周末血压明显下降(P<0.05),组间血压降幅差异无统计学意义。两组治疗前后一般项目及生化指标差异无统计学意义。两组24h平均收缩压及平均舒张压、昼平均收缩压及昼平均舒张压、夜平均收缩压及夜平均舒张压、baPWV及IGF-1较治疗前明显下降(P<0.05),组间差异无统计学意义。结论:依普利酮与氯沙坦均能明显降低轻中度原发性高血压患者动脉僵硬度和IGF-1水平,但两者改善程度无差异。Objective：To explore the effect of eplerenone and losartan on arterial stiffness and insulin-like growth factor 1（IGF-1） in patients with mild to moderate essential hypertension. Method：A total of 84 patients with mild to moderate essential hypertension（90 mmHg≤diastolic pressure 110 mmHg,and 140 mmHg ≤systolic blood pressure 180 mmHg,1 mmHg=0.133 kPa） was divided into eplerenone group and losartan group（42 cases each）.Each patient had daily oral eplerenone or losartan 50 mg once respectively.Every 2 weeks return visited once.The hepatorenal function,electrolyte,blood sugar,blood fats,blood routine test,urine routine test and automatic ABPM（blood pressure monitor）,baPWV（the pulse wave velocity） and IGF-1 were detected before and after 12 weeks treatment. Result：Blood pressures reduced significantly after treatment 12 weeks in two groups（P0.05）,but there was no difference between two groups.The general data had no difference between two groups.Compared with treatment before,the 24 hourly average systolic pressure and average diastolic pressure,daytime average systolic pressure and average diastolic pressure,nighttime average systolic pressure and average diastolic pressure,baPWV and IGF-1 decreased significantly after treatment,but there was no obvious difference between two groups. Conclusion：Eplerenone and losartan can significantly reduce arterial stiffness and IGF-1 level in patients with mild to moderate essential hypertension,but there was no obvious difference between the two groups.

关 键 词：原发性高血压 依普利酮 氯沙坦 脉搏波传导速度 胰岛素生长因子-1 

分 类 号：R544.1[医药卫生—心血管疾病]