内感受对成瘾行为的诱导及其岛叶的调控机制  

The Role of Interoception and Insular Cortex in Addiction

作　　者：李春禄[1,2] 朱宁[1] 李勇辉[1] 孟肖路[1,2] 高军[1,2] 隋南[1] 

机构地区：[1]中国科学院心理研究所,中国科学院心理健康重点实验室,北京100101 [2]中国科学院大学,北京100049

出　　处：《生物化学与生物物理进展》2013年第1期15-21,共7页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(31070911;31170988);国家重点基础研究发展计划(973)(2009CB522002)资助项目~~

摘　　要：内感受是机体对自身生理状态的感觉.近年来,越来越多的研究证据表明,内感受可以调控成瘾行为,岛叶是其发挥作用的重要神经基础之一.目前,对岛叶作用机制的研究正受到高度重视.本文从岛叶的基本结构和功能出发,结合近几年来岛叶调控成瘾行为、行为抑制以及情感决策的重要发现,讨论岛叶在成瘾发生及发展过程中的可能作用及其机制,并根据已有的实验证据,试图提出较为合理的研究展望,以推动相关神经环路和神经化学机制研究的深入.Interoception is the sense of the physiological condition of the body.Recent studies suggested that interoception is involved in drug addiction and insular cortex is a key anatomical position.The neural mechanisms underlying such phenomena attract growing attention.In an effort to develop working hypotheses for future investigation,the article first reviewed the evidence of interoceptive regulation of addiction,and subsequently presented human and animal data that suggest a central role of the insular cortex in mediating interoception and addiction.On this basis,we proposed potential neurobiological mechanisms through which insular cortex may mediate drug addiction.Further,possible functional roles of neurotransmitters in the insular cortex are discussed in the context of drug addiction.

关 键 词：内感受 岛叶 成瘾 

分 类 号：Q426[生物学—神经生物学]