亚甲基四氢叶酸还原酶基因多态性与突发性聋发病风险的Meta分析  

A Meta-Analysis of polymorphism in Methylenetetrahydrofolate Reductase Genes and Risks for Sudden Sensorineural Hearing Loss

作　　者：冯文静 刘博[2,3] 陈崇学 彭晓霞[4] 杨剑 

机构地区：[1]清华大学第一附属医院耳鼻咽喉科,北京100016 [2]北京市耳鼻咽喉科研究所 [3]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科中心耳鼻咽喉头颈科学教育部重点实验室,北京100005 [4]首都医科大学公共卫生与家庭医学院流行病与卫生统计学系,北京100069 [5]民航医学中心耳鼻咽喉科,北京100123

出　　处：《中华耳科学杂志》2012年第4期498-503,共6页Chinese Journal of Otology

基　　金："十一五"国家科技支撑计划资助项目(2007BAI18B13)

摘　　要：目的运用Meta分析的方法分析亚甲基四氢叶酸还原酶基因C677T多态性与突发性聋发病相关性。方法计算机检索PUBMED、EMBASE、Cochrane图书馆(英文)和中国生物医学文献数据库(CBM)(中文),查找亚甲基四氢叶酸还原酶基因C677T多态性与突发性聋发病相关的临床研究,对纳入的文献进行严格方法学质量评价。应用RevMan4.2软件进行统计分析。结果共有7篇文献纳入研究,累计病例组388例,对照组2921例。方法学质量评价结果显示,4个研究为A级,3个研究为B级,总体研究质量较高。Meta分析结果提示亚甲基四氢叶酸还原酶基因C677T多态性在基因型水平[OR=1.79>1,95%CI=(1.06,3.02),P=0.03]和等位基因水平[OR=1.53>1,95%CI=(1.08,2.17),P=0.02]均可能增加突发性聋的发病风险。结论本研究提示亚甲基四氢叶酸还原酶基因C677T多态性可能增加突发性聋发病风险,本系统评价纳入的研究相对较少,上述结论尚需开展多中心大样本量的高质量研究进一步证实。Objective To investigate the association between MTHFR C677T polymorphism and the risk for sudden sen- sorineural hearing loss （SSNHL） using meta-analysis methodology. Methods Databases including PUBMED, EMBASE, Co- chrane Library and CBM were searched to collect case control studies on the correlation between MTHFR C677T polymor- phism and sudden sensorineural hearing loss. Only high quality studies were included. All analyses were conducted with the Review Manager Version 4.2 software. Results A total of 7 studies were included, involving 388 patients and 2921 controls. The quality assessment indicated Level A quality in 4 studies and Level B quality in 3 studies. Meta-analysis showed that the MTHFR C677T polymorphism frequencies at genotypes and alleles levels were associated with increased risk for SSNHL [OR= 1.79 and 1.53, 95%CI=（1.06,3.02） and （1.08,2.17）, and P=0.03 and 0.02,respectively]. Conclusions The Meta-analysis sug- gests that the MTHFR C677T polymorphism may be a genetic risk factor for sudden sensorineural hearing loss. However, this conclusion remains to be confirmed by high-quality, large-scale and muhi-center studies.

关 键 词：聋 突发性 META分析 亚甲基四氢叶酸还原酶基因 病因 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]