银屑病性关节炎患者Th17和Treg细胞的变化及意义  

Expression of Th17/Treg Cell in Patients with Psoriasis Arthritis and Its Clinical Significance

作　　者：陈晋广[1,2] 赖维[1] 姜昱[3] 

机构地区：[1]中山大学附属第三医院皮肤科,广州510630 [2]浙江省台州市立医院皮肤科,浙江台州318000 [3]广东省中山市人民医院皮肤科,广东中山528403

出　　处：《中国医学科学院学报》2012年第6期617-620,共4页Acta Academiae Medicinae Sinicae

基　　金：浙江省医药卫生科技计划(2011KYB141;2012KYA184);中国博士后科学基金(2012M521655)~~

摘　　要：目的研究血清Th17和Treg细胞在银屑病性关节炎(PsA)发病机制中的作用。方法采用酶联免疫吸附方法 (ELISA)检测35例PsA患者和30例正常对照者血清中的白细胞介素(IL)-17和人转化生长因子(TGF)-β1的水平,流式细胞分析法检测外周血Th17细胞和CD4+CD25+Treg细胞亚群。结果 PsA患者外周血Th17/Treg显著高于对照组(P<0.05),血清中IL-17水平也明显高于对照组(P<0.05),TGF-β1水平明显低于对照组(P<0.05)。结论Th17/Treg细胞以及相关细胞因子IL-17、TGF-β1可能参与了PsA的发病过程。Objective To investigate the change of Th17/Treg cell in patients with psoriasis arthritis（PA） and its clinical significance.Methods The levels of IL-17 and TGF-β1 were measured by enzyme-linked immunosorbent assay（ELISA） in PA patients（n=35） and healthy controls（n=30）.The frequencies of Th17 and Treg in the peripheral blood were detected by flow cytometry.Results Compared with the healthy controls,Th17/Treg in peripheral blood were significantly increased（P0.05）,Th17-related cytokine IL-17 significantly increased（P0.05）,and TGF-β1 significantly decreased（P0.05） in the PA patients.Conclusion Th17/Treg cell and the related cytokines IL-17 and TGF-β1 may be involved in the pathogenesis of PA.

关 键 词：银屑病性关节炎 TH17 TREG细胞 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]