慢性乙型肝炎病毒感染对骨关节结核病患者实验室检测结果的影响  

Evaluation of the effect of chronic virus infection on laboratory tests results in patients withosteoarticular tuberculosis.

作　　者：刘云[1] 杨辉[2] 马克[3] 吴爱武[2] 张明霞[3] 邓群益[3] 周伯平[3] 陈心春[3] 

机构地区：[1]江西省石城县人民医院,石城县342700 [2]广州医学院 [3]深圳市第三人民医院

出　　处：《中华实验和临床病毒学杂志》2012年第6期450-452,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的探讨慢性乙肝病毒感染对骨关节结核病患者实验室检测的影响，为骨关节结核合并病毒感染患者的实验室检测结果的应用提供指导依据。方法收集2008年6月至2012年6月期间曾在深圳市第三人民医院进行住院治疗并确诊为骨关节结核病的121例患者的临床资料，调查其合并慢性病毒感染情况，并分析合并病毒感染对结核病实验室检测结果的影响。结果在121例骨关节结核患者中，有30例骨关节结核患者合并有HBV感染，2例骨关节结核患者合并HIV感染，1例骨关节结核患者同时合并感染HBV、HCV及HIV。与单纯的骨关节结核患者相比，合并慢性乙型肝炎病毒感染的骨关节结核患者在组织结核菌抗酸染色、组织结核菌培养、组织结核菌DNA、血清抗结核抗体、以及采用ELISPOT法检测的外周血结核菌特异性r-干扰素的检出率的差别均无统计学意义；血沉、C反应蛋白、肝功能异常情况等感染相关指标检测结果的差别也不具有统计学意义。结论慢性乙型肝炎病毒感染对骨关节结核病患者结核诊断实验室检查结果无明显影响，在评判相关实验室检查结果时可参照单纯骨关节结核。Objective To evaluate the effect of chronic virus infection on laboratory tests results in patients with osteoarticular tuberculosis. Methods A total of 121 patients with osteoarticular tuberculosis, who were hospitalized in Shenzhen Third People＇s Hospital during June 2008 to June 2012, were recruited for analysis. Clinical laboratory tests results were collected for comparison between patients with or without chronic co-infection with virus. Results Among the 121 patients, thirty patients were co-infected with hepatitis B virus （HBV） , two were with Human immunodeficiency virus （HIV）, and one was co-infected with HBV, HIV and hepatitis C virus （HCV）. Compared to patients with osteoarticular tuberculosis without HBV/HCV/HIV infection, patients with chronic HBV/HCV/HIV virus infection had similar positive rate of laboratory tests including tissue smear acid-fast bacilli （AFB） staining, tissue Mycobacterium tuberculosis （Mtb） culture, tissue Mtb DNA detection, serological test of antibodies against Mtb, and Mtb. antigen- specific interferon-gamma release assay. Similar results were also found for erythrocyte sedimentation rate, C-reative protein level and liver function including Alanine aminotransferase and Aspartate Aminotransferase. Conclusion Chronic infection with HBV/HCV in patients with have no obvious effect on clinical laboratory tests related to tuberculosis.

关 键 词：结核 骨关节 肝炎 乙型 慢性 

分 类 号：R512.62[医药卫生—内科学]