磨损颗粒引起人工关节无菌性松动的研究与进展  

Research progress of the wear particles-induced aseptic prosthesis loosening

作　　者：李海亚[1] 查振刚[1] 

机构地区：[1]暨南大学附属第一医院骨科,广东省广州市510632

出　　处：《中国组织工程研究》2012年第48期9059-9063,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:研究显示磨损颗粒诱导的假体周围骨溶解是导致人工假体无菌性松动的最主要原因。目的:对磨损颗粒引起人工关节假体无菌性松动在分子生物学方面的研究现状及新进展作一综述。方法:应用计算机检索CNKI和Pubmed数据库中1991年1月至2012年3月关于人工关节磨损颗粒的文章,在标题和摘要中以"关节置换,磨损颗粒,假体松动"或"arthroplasty,wear particles,loosening of the prosthesis"为检索词进行检索。最终选择30篇文献进行综述。结果与结论:假体无菌性松动是人工关节置换后手术失败的最主要原因,在此过程中磨损颗粒起到关键性作用。通过对细胞因子及信号传导途径研究的综述,为预防及药物治疗假体无菌性松动提供理论依据。然而,假体的无菌性松动受多种因素的影响,所以预防应从整体着眼,全面深入研究,为假体的松动防治提供方向。BACKGROUND：Studies have shown that the wear particle-induced periprosthesis osteolysis is the main reason leading to aseptic loosening of prosthesis. OBJECTIVE：To review the research progress of the wear particle-induced aseptic prosthesis loosening in molecular biology. METHODS：A computer-based search was performed on the CNKI database and PubMed database from January 1991 to March 2012 for the articles related to the wear particles of prosthesis.The key words of ＂arthroplasty,wear particles,loosening of the prosthesis＂ in English and Chinese were used to search the articles in the title and the abstract.Finally,a total of 30 artilces were included to review.RESULTS AND CONCLUSION：Aseptic loosening of the prosthesis is the main reason for the failure of the surgery after artificial joint replacement,and the wear particles play an important role during the process.The synthesis on the research of cytokines and signal transduction pathways provides a theoretical basis for prevention and drug treatment of prosthesis aseptic loosening.However,prosthesis aseptic loosening can be influenced by a variety of factors,prevention should be the overall focused and comprehensive studied which can provide direction for the prevention of prosthesis loosening.

关 键 词：关节置换 磨损颗粒 无菌性 松动 研究进展 

分 类 号：R687.4[医药卫生—骨科学]