应激诱导的MicroRNAs调控作用研究进展  

Advances of Stress Induced MicroRNAs Modulation Roles

作　　者：冀国华[1] 吕柯[1] 曲丽娜[1] 李莹辉[1] 

机构地区：[1]中国航天员科研训练中心,航天医学基础与应用国家重点实验室,北京100094

出　　处：《航天医学与医学工程》2012年第6期449-453,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金(30973686);国家科技支撑计划(2009BAK59B01);航天医学基础与应用国家重点实验室研究基金自主项目(SMFA09A06)

摘　　要：MicroRNAs是一种内源性的长约22个核苷酸的非编码RNA。近年的研究发现miRNAs不仅参与了细胞发育、增殖、凋亡、分化等几乎所有的生理过程,而且在疾病发生,细胞对外界刺激的响应等病理过程中发挥着重要作用。外界刺激影响miRNAs的表达,miRNAs通过调控靶基因的表达对外界刺激作出响应。本文就miRNAs研究最新进展及miRNAs在各种应激中的调控作用作一综述,并对miRNAs在航天医学中的研究及应用进行了分析与展望。MicroRNAs （miRNAs） are endogenous 22 nucleotide noncoding RNA. Recent years, studies dem- onstrated that miRNAs played important roles not only in cell development, proliferation, apoptosis and differ- entiation, almost all the physiological process; but also in the pathological process like diseases and cellular responses to environmental stimuli. Environmental stimuli affected the expression of miRNAs. MiRNA modula- ted target genetic expression to response. This paper reviewed the latest progress of miRNA studies and their function in stress responses. Furthermore, the study and application of miRNAs in space medicine were ana- lyzed and vrosDected.

关 键 词：MIRNAS 基因调控 应激 空间环境 

分 类 号：R854[医药卫生—航空、航天与航海医学]