吸附^(99m)TcO_4^-的铁碳复合磁性药物载体在体内靶向分布研究  

A Study on Targeted Distribution of ^(99m)TcO_4^- Absorbed Magnetic Iron-carbon Composite Drug Carrier in Vivo

作　　者：张光明[1] 朱汇庆[1] 刘从进[1] 王渊恺[1] 刘兴党[1] 黄广建[2] 胡承恩[2] 甘军[2] 

机构地区：[1]复旦大学附属华山医院核医学科 [2]复旦大学附属华山医院普外科

出　　处：《中国医学计算机成像杂志》2012年第6期538-541,共4页Chinese Computed Medical Imaging

基　　金：国家自然科学基金(No 30471682)~~

摘　　要：目的:探索铁碳复合磁性载体吸附^(99m)TcO_4^-开展肝脏靶向治疗的可行性。方法:12只新西兰白兔随机分为3组:^(99m)TcO_4^-水溶液组、未加磁场^(99m)TcO_4^-铁碳复合磁性载体组和外加磁场^(99m)TcO_4^-铁碳复合磁性载体组。左肝动脉置管分别注射该组剂型后利用SPECT分别对每只兔的肝脏、肺脏及甲状腺部位设定ROI,测定其部位在各时间点ROI放射性计数,并进行组间比较。结果:铁碳复合磁性载体对^(99m)TcO_4^-具有良好的吸附性。^(99m)TcO_4^-标记铁碳复合磁性载体加脉冲磁场组,在各时间点肝脏放射性计数均较其余2组明显增高。结论:脉冲磁场作用下磁性载体在靶区器官浓度增高、停留时间延长,从而增加药物有效作用浓度及时间,同时可减少药物在非靶区组织分布,减少不良反应。Purpose： To explore the feasibility of liver targeted treatment by using iron and carbon compound magnetic carrier to absorb 99mTcO4-. Methods： Twelve New Zealand white rabbits were randomly divided into 3 groups： 99mTcO4-marked water solution group, 99mTcO4-marked iron and carbon compound magnetic carrier without external use of magnetic field group and 99mTcO4-marked iron and carbon compound magnetic carrier with external application of magnetic field group. After injection of respective dose of above mentioned 3 different preparations via the tube which was inserted into the artery of the left liver lobe, the radioactivity counts of the liver, lung and thyroid of each rabbit in each time point were measured on the SPECT by ROI method, and the results among these 3 groups were compared. Results： The iron and carbon compound magnetic carrier can absorb 99mTcO4- very well. The radioactive counts of the liver region at all time points of the group with 99mTcO4-marked iron and carbon compound magnetic carrier in addition to the external application of pulse magnetic field were noticeably higher than those of other 2 groups. Conclusion： With the impact of pulse magnetic field, the magnetic carriers have an increased concentration in targeted organs and stay longer time, which resulting in an increased concentration of medicine and effective time there while decreasing the distribution of medicine in non-targeted organs, tissues, hence less side effect and undesired reaction will occur.

关 键 词：磁靶向治疗 药物载体 磁场 ~99mTcO_4^- SPECT 

分 类 号：R943[医药卫生—药剂学]