突触形成调控蛋白的研究与进展  

Research progress in proteins regulating synaptogenesis

作　　者：黄云[1] 郭伟韬[1] 王斌[1] 

机构地区：[1]广东医学院附属医院骨科,广东省湛江市524001

出　　处：《中国组织工程研究》2012年第45期8524-8529,共6页Chinese Journal of Tissue Engineering Research

基　　金：广东省自然科学基金项目(S2011010004096);广东省医学科研基金资助项目(A2009477)~~

摘　　要：背景:干细胞在体外也被证实可以分化为神经元细胞,然而干细胞分化成神经细胞后如何形成突触连接而实现信息传递功能,以及突触形成的调控机制是什么,这些尚未可知。目的:通过对2000年以来影响突触形成调控蛋白的实验研究检索,总结这些蛋白在突触研究中的作用。方法:以"synapse、synaptogenesis"为检索词,应用计算机检索中国知网和pubmed数据库相关文章,排除重复性研究,保留39篇文章做进一步分析。结果与结论:突触形成的过程主要包括3个方面的相关内容:①突触结构的形成。②一些突触由无活性到有活性的转换。③非必要突触的消除。而与之相关的蛋白及其功能得以肯定并得到初步研究的主要有血小板反应蛋白、突触分化诱导基因产物、突触细胞黏附分子、主要组织相容性复合物Ⅰ型、肌细胞增强因子2、脆性X智力低下蛋白等。这些蛋白在突触的形成,发育和成熟过程中发挥着重要作用。BACKGROUND： Stem cells have been shown to differentiate into neuronal cells in vitro. But how do neuronal cells form synaptic connections after stem cell differentiation to achieve the information transfer function and what is the mechanism underlying synaptogenesis remain unclear. OBJECTIVE： To summarize the effects of proteins regulating the synaptogenesis by retrieving the experimental studies describing these proteins influencing synaptogenesis since 2000. METHODS： A computer-based online retrieval of CNKI and PubMed databases was performed to search related papers using the key words synapse and synaptogenesis. After excluding repeated studies, 39 papers were included in the final analysis. RESULTS AND CONCLUSION： The synaptogenesis can be divided into three related aspects： （1） formation of synaptic structure; （2） transition of some synapses from silent to active; （3） elimination of unnecessary synapses. Synaptogenesis associated proteins and their functions have been confirmed and preliminarily studied. These proteins include thrombospondins, synapse differentiation induced gene product, synaptic cell adhesion molecule, major histocompatibility complex I, myocyte enhancer factor 2, and fragile X mental retardion protein. These proteins play a vital role in synapse formation, development and maturation.

关 键 词：突触 突触形成 蛋白 脊髓损伤 文献综述 

分 类 号：R318[医药卫生—生物医学工程]