钙信号转导对细胞凋亡的影响  

Effect of Calcium Signal Transduction on Apoptosis

作　　者：徐欢成[1] 郑明学[1] 古少鹏[1] 白瑞[1] 

机构地区：[1]山西农业大学动物科技学院,山西太谷030801

出　　处：《动物医学进展》2013年第1期112-115,共4页Progress In Veterinary Medicine

基　　金：国家自然基金项目(30771619);山西省自然基金项目(20041094);山西省科技攻关项目(993020-1)

摘　　要：钙离子作为生命体最普遍的一种信号转导因子,在细胞的凋亡进程中起到了重要的调节作用。以往的研究认为细胞内钙离子浓度升高是凋亡进行到后期所引起的间接结果,但近年来研究发现钙离子作用于细胞凋亡的各个层次,通过多种方式精细调控细胞凋亡进程,构成了细胞凋亡过程中复杂的钙调控网络。论文总结了近几年来关于钙信号转导对细胞凋亡影响的研究成果,从钙离子与内质网、线粒体、Bcl-2家族蛋白和细胞凋亡的关系出发,就钙信号转导对细胞凋亡的影响进行讨论和分析。Calcium ion is one of the most common signal transducfactors in the process of the life that play an important role in the regulation of apoptosis. It suggests that the intracellular calcium concentration in- creased due to the indirect result in the late step of apoptosis in the previous studies, but recent studies have found that calcium plays an important role in the process of apoptosis at all levels through the fine regulation in a variety of ways, and constitutes complex regulatory network of calcium during apoptosis. This paper summarized the research in the calcium signal transduction of apoptosis in the recent years, from the perspective of the relationship between calcium and endoplasmic reticulum, mitochondria, Bcl-2 family proteins and apoptosis to discuss and analyse the effect of the calcium signal transduction on apoptosis.

关 键 词：钙离子 线粒体 内质网 BCL-2家族蛋白 细胞凋亡 

分 类 号：S852.3[农业科学—基础兽医学]