蛋白Z和蛋白Z依赖的蛋白酶抑制物在妊娠期高血压疾病中的变化及其意义  

The change and the significance of protein Z and protein Z-dependent protease inhibitor in hypertensivedisorders in pregnancy

作　　者：黄斌伦[1] 蒋旭峰 陆晓东[3] 程屹[3] 徐燕[3] 王敏[1] 徐秋仙[3] 何云芹[3] 

机构地区：[1]金华职业技术学院医学院,321017 [2]金华市妇幼保健院 [3]金华市中心医院

出　　处：《中国综合临床》2013年第1期16-19,共4页Clinical Medicine of China

基　　金：金华市科学技术研究计划项目（2009-3-037）

摘　　要：目的探讨妊娠期高血压疾病妇女血浆蛋白Z（PZ）和蛋白z依赖的蛋白酶抑制物（ZPI）水平变化及其临床意义。方法选择正常未孕妇女50名（未孕组）、正常孕妇100名（正常孕妇组）、妊娠期高血压疾病30例（妊娠期高血压组）、轻度子痫前期25例（轻度子痫前期组）和重度子痫前期30例（重度子痫前期组）；妊娠期高血压疾病患者分娩的胎儿生长受限组20例（胎儿生长受限组），胎儿生长正常35例（胎儿生长正常组）；采用酶联免疫吸附试验竞争法测定其血浆PZ和ZPI浓度。结果Pz和ZPI血浆含量自未孕组到正常孕妇组、妊娠期高血压组、轻度子痫前期组和重度子痫前期组逐渐下降[PZ含量分别为（374．79±133．51）、（329．00±78．53）、（258．56±51．60）、（246．40±132．23）、（214．27±82．46）ng／L；ZPI含量分别为（160．47±74．18）、（139．05±78．07）、（130．86±31．36）、（127．25±32．81）、（122．56±51．51）ng／L]，PZ各组之间差异有统计学意义（F=5．209，P〈0．001），重度子痫前期组与未孕组、正常孕妇组比较显著下降，差异有统计学意义（P均〈0．05），轻度子痫前期组与未孕组、正常孕妇组比较显著下降，差异有统计学意义（P均〈0．05），但其他各组之间比较差异无统计学意义（P均〉0．05）。但ZPI各组之间差异无统计学意义（F=0．758，P〉0．05）。在妊娠期高血压疾病孕妇中，胎儿生长受限组的PZ和ZPI含量低于胎儿生长正常组，但差异无统计学意义（t=1．251，P=0．229；t=0．775，P=0．556）。结论抗凝物质PZ和ZPI含量下降可能是妊娠期高血压疾病发生的一个危险因素，并且与妊娠期高血压疾病的严重程度及胎儿生长受限有关。Objective To explore the level and clinical significance of blood plasma protein Z （PZ） and protein Z-dependent protease inhibitor （ZPI） in pregnant women with hypertensive disorders . Methods Fifty cases of normal non-pregnant women, 100 cases of normal pregnancy women,30 cases of pregnancy women with hypertensive disorders, 25 cases of mild preeelampsia, 30 cases of severe preeclampsia;20 cases of fetal growth retardation（FGR） borne by pregnancy women concurred with hypertension and 35 eases of normal fetal growth were chosen to determine their level of blood plasma PZ and ZPI, which were tested using competitive enzyme-linked immunoadsordent assay. Results The level of blood plasma PZ and ZPI decreased gradually from the non-pregnant women to normal pregnancy women, hypertensive disorders in pregnancy, mild preeclampsia and severe preeclampsia,with the content of PZ （ 374. 79 ± 133.51 ） ng/L, （ 329. 00 ± 78. 53 ） ng/L, （ 258.56 ± 51.60） ng/L, （246.40 ± 132. 23 ）ng/L and （214.27 ± 82.46 ）ng/L separately;and the content of ZPI was （ 160. 47 ±74. 18） ng,/L, （ 139. 05 ± 78. 07 ） ng/L, （ 130. 86 ± 31.36 ） ng/L, （ 127.25 ± 32. 81 ） ng/L and （ 122. 56 ± 51.51 ） ng/L respectively. There were significant differences in PZ content among different groups （ F = 5. 209, P 〈 0. 001 ）. The content of PZ in severe preeclampsia group decreased significantly compared with normal non-pregnant women group and normal pregnancy women group （ P 〈 0. 05 ） while the content of PZ in mild preeclampsia group decreased greatly compared with normal non-pregnant women and normal pregnaney women group（ P 〈0. 05 ）. But there exist no significant differences between other groups（ P 〉 0. 05 ）. There are no great differences in ZPI between the groups （ F = 0. 758, P 〉 0.05 ） in pregnant women with hypertensive disorders, the level of PZ and ZPI in FGR group was lower than that in normal fetal growth group, but with no significant differences （ t = 1.25

关 键 词：妊娠期高血压疾病 蛋白Z 蛋白Z依赖的蛋白酶抑制物 胎儿生长受限 

分 类 号：R714[医药卫生—妇产科学]