机构地区:[1]珠海金鼎自愿戒毒医院,珠海519085 [2]广州中医药大学,广州510405 [3]惠州罗浮山自愿戒毒医院,惠州516133 [4]万健医疗门诊部,广州510400
出 处:《中国药物滥用防治杂志》2012年第5期256-261,共6页Chinese Journal of Drug Abuse Prevention and Treatment
摘 要:目的:通过对"清浊祛毒丸"在氯胺酮(K粉)滥用引发泌尿系损害患者的临床治疗效果观察,探索科学有效的治疗方法,缓解或消除氯胺酮滥用对机体的生理损害。方法:设中成药"清浊祛毒丸"观察组和抗生素"头孢呋辛钠"加"地塞美松"对照组。对两组共73例氯胺酮滥用引起泌尿系症状患者进行临床治疗效果观察,及血尿常规等实验室检查的比较。结果:"清浊祛毒丸"和抗生素"头孢呋辛钠"加"地塞美松"治疗均可明显的缓解包括尿痛、尿急、尿频、血尿、尿失禁等尿路刺激症状,降低尿常规中的红细胞、白细胞等。临床治疗初日和治疗20日的结果比较两组均有显著性差异。但两组治疗效果比较统计学分析无显著性差异。结论:氯胺酮滥用可以导致严重的泌尿系功能损害。"清浊祛毒丸"和"头孢呋辛钠"加"地塞美松"在缓解和治疗尿路刺激症状方面效果显著;但"清浊祛毒丸"在康复治疗方面更有优势,既有抗生素加激素的抑菌消炎的作用又具改善其他戒断症状的作用,体现了中医治病求本和标本兼治的特色,又具有抗生素加激素对此类炎症的治疗效果,而且在减少抗生素滥用和糖皮质激素滥用及其毒副作用方面更具临床实用价值以及重要社会意义。"清浊祛毒丸"是治疗氯胺酮滥用伴泌尿系功能损害的有效方法之一。Objective:In seeking a scientific and effective treatment for ketamine abusers,an observation was conducted on the clinical symptoms of the ketamine abusers who used Chinese patent medicine "Qingzhuoqudu pill" to cure urinary system damages induced by ketamine abuse.The observation indicates that the Chinese patent medicine can reduce or eliminate the physiological damages caused by ketamine.Methods:Ketamine abusers were divided into two groups:one is observation group that take Chinese patent medicine "Qingzhuoqudu pill",the other is comparing group that take antibiotics such as cefuroxime plus dexamethasone.73 ketamine abusers who got urinary system damages due to abuse of ketamine were given a clinical observation as well as comparison of their lab urine test.Result:Medical treatment of both Chinese patent medicine "Qingzhuoqudu pill" and antibiotics cefuroxime plus dexamethasone can obviously ease the symptoms of urinary system tract irritation such as dysuria,urinary frequency and urgency,hematuria,urinary incontinence,lumbago and weak legs,And the red blood cell and leukocyte etc.in urine test were also reduced.Significant differences were found in a comparison conducted on the results of the clinical treatment on the first day and on the 20th day.However,the statistics analysis of the results of clinical treatment in the two groups did not show significant differences.Conclusion:Ketamine abuse can cause serious damage to the urinary tract function.The Chinese patent medicine "Qingzhuoqudu pill" and antibiotics cefuroxime plus dexamethasone both have significant effects to relieve urinary tract irritation.However the Chinese patent medicine "Qingzhuoqudu pill" has an advantage on rehabilitation because it has both antibacterial diminish inflammation effect of antibiotics plus hormones and the other withdrawal symptoms improvement's function,which can reflects the Chinese medicine's characteristics of treating both principal and secondary aspect of disease and treating disea
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