Study of Combined Use of Clomiphene Citrate and Gonadotropins on the Infertile Patients with PCOS  

作　　者：Su-ying LIU Xiong LI Yu ZHENG Bin TENG Ying CAO Xiao-xi SUN 

机构地区：[1]Obstetrics & Gynecology Hospital, Shanghai Jiai Genetics & 1VF Institute, Fudan University, Shanghai 200011, China [2]Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China

出　　处：《Journal of Reproduction and Contraception》2012年第3期159-168,共10页生殖与避孕（英文版）

摘　　要：Objective To investigate the efficacy and safety of combined use of clomiphene citrate （CC） and gonadotropins （Gn） on the infertile patients with PCOS. Methods A total of 367 infertile patients with PCOS were included in this retrospective study. Patients received CC from menstrual cycle day 3 until the day of triggering and human menopausal gonadotrophins （hMG） from menstrual cycle day 5 until the ovulation day. Gn duration and doses, serum LH and estradiol levels, transferable embryos, incidence of OHSS, frozen-thawed embryo implantation and clinical pregnancy rates were compared among CC plus hMG, long and short protocols. Results Gn duration and doses, blood estrogen level transferable embryos and incidence of OHSS in the group of CC plus hMG were decreased significantly than those of long and short protocols. No differences were observed in the frozen-thawed embryo implantation and clinical pregnancy rates among three groups. Conclusion Mild stimulation of CC combined with hMG on infertile patients with high risk for OHSS is safe and efficient.Objective To investigate the efficacy and safety of combined use of clomiphene citrate （CC） and gonadotropins （Gn） on the infertile patients with PCOS. Methods A total of 367 infertile patients with PCOS were included in this retrospective study. Patients received CC from menstrual cycle day 3 until the day of triggering and human menopausal gonadotrophins （hMG） from menstrual cycle day 5 until the ovulation day. Gn duration and doses, serum LH and estradiol levels, transferable embryos, incidence of OHSS, frozen-thawed embryo implantation and clinical pregnancy rates were compared among CC plus hMG, long and short protocols. Results Gn duration and doses, blood estrogen level transferable embryos and incidence of OHSS in the group of CC plus hMG were decreased significantly than those of long and short protocols. No differences were observed in the frozen-thawed embryo implantation and clinical pregnancy rates among three groups. Conclusion Mild stimulation of CC combined with hMG on infertile patients with high risk for OHSS is safe and efficient.

关 键 词：PCOS clomiphene citrate （CC） mild stimulation OHSS 

分 类 号：Q959.468[生物学—动物学] TS103.224[轻工技术与工程—纺织工程]