Synthesis of a dendritic estrogen cluster:A potential tool for studies of nuclear versus extranuclear pathways of estrogen actions  

作　　者：Jian Chen Hu Zheng Yan Song Yu Feng Liang Qing Rong Qi 

机构地区：[1]Functional Food(Drug) Laboratory,Institute of Agro-Product Processing Science and Technology,Sichuan Academy of Agricultural Science [2]Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education,Department of Medicinal Chemistry,West China School of Pharmacy,Sichuan University

出　　处：《Chinese Chemical Letters》2012年第12期1319-1322,共4页中国化学快报（英文版）

基　　金：supported by the National Key Basic Research Program of China(973 Program) Foundation (2010CB529905)

摘　　要：A novel estrogen dendrimer has been synthesized through a combination of divergent and convergent approaches in 9 practical steps and in good yields. It was characterized and confirmed by elemental analysis, FT-IR, MS, 1H NMR, 13C NMR. The dendrimer contains 16 estrone units and is potentially a useful tool for the studies of estrogen actions.A novel estrogen dendrimer has been synthesized through a combination of divergent and convergent approaches in 9 practical steps and in good yields. It was characterized and confirmed by elemental analysis, FT-IR, MS, 1H NMR, 13C NMR. The dendrimer contains 16 estrone units and is potentially a useful tool for the studies of estrogen actions.

关 键 词：Estrogen dendrimer Synthesis Nuclear and extranuclear Receptor 

分 类 号：O641[理学—物理化学]