Synthesis,structural characterization and antibacterial activity of diorganotin(Ⅳ) complexes with ONO tridentate Schiff bases containing pyridine ring  

作　　者：Tahereh Sedaghat Razieh Habibi Hossein Motamedi Hamid Reza Khavasi 

机构地区：[1]Department of Chemistry,College of Sciences,Shahid Chamran University [2]Department of Biology,College of Sciences,Shahid Chamran University [3]Department of Chemistry,Shahid Beheshti University,G. C.,Evin

出　　处：《Chinese Chemical Letters》2012年第12期1355-1358,共4页中国化学快报（英文版）

基　　金：Support of this work by Shahid Chamran University,Ahvaz,Iran is gratefully acknowledged

摘　　要：Five organotin（IV） complexes, were obtained by reaction of SnR2C12 （R = Ph, Me, Bu） with ONO donor Schiff bases. The synthesized complexes have been investigated by elemental analysis and IR, 1H NMR, and ll9Sn NMR spectroscopy. These data show that the Schiff base acts as a tridentate dianionic ligand and coordinates via the imine nitrogen and two oxygen atoms. The X- ray crystallography of complex 4 shows a dimeric structure for this molecule. The in vitro antibacterial activities of the Schiff bases and their complexes have been evaluated against Gram-positive （Bacillus subtilis and Staphylococcus aureus） and Gram-negative （Escherichia coli and Pseudomonas aeruginosa） bacteria and compared with the standard antibacterial drugs.Five organotin（IV） complexes, were obtained by reaction of SnR2C12 （R = Ph, Me, Bu） with ONO donor Schiff bases. The synthesized complexes have been investigated by elemental analysis and IR, 1H NMR, and ll9Sn NMR spectroscopy. These data show that the Schiff base acts as a tridentate dianionic ligand and coordinates via the imine nitrogen and two oxygen atoms. The X- ray crystallography of complex 4 shows a dimeric structure for this molecule. The in vitro antibacterial activities of the Schiff bases and their complexes have been evaluated against Gram-positive （Bacillus subtilis and Staphylococcus aureus） and Gram-negative （Escherichia coli and Pseudomonas aeruginosa） bacteria and compared with the standard antibacterial drugs.

关 键 词：Schiff base Antibacterial activity Organotin（IV） Crystal structure 119Sn NMR 

分 类 号：O627[理学—有机化学]