Synthesis of an antimetastatic tetrasaccharide β-D-Gal-(1→4)-β-d-GlcpNAc-(1→6)-α-D-Manp-(1→6)-β-D-Manp-OMe  

作　　者：Kai Jun Liao Xiao Feng Jin Xiang Bao Meng Chen Li Zhong Jun Li 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University

出　　处：《Chinese Chemical Letters》2012年第12期1371-1374,共4页中国化学快报（英文版）

基　　金：supported by the National Basic Research Program of China(973 program,No.2012CB822100);the National Natural Science Foundation of China(No.20972012)

摘　　要：An antimetastatic tetrasaccharide β-D-Gal-（1 → 4）-β-D- GlcpNAc-（1 →6）-α-D-Manp-（1 → 6）-β-D-Manp-OMe, was syn- thesized with two approaches. The first approach was a conventional method employing thioglycoside and Koenigs-Knorr glycosylation reaction in 24% overall yield. The second one was a novel route through the azidoiodo-glycosylation strategy by using 2-iodo-2-deoxylactosyl azide as the donor in 36% overall yield.An antimetastatic tetrasaccharide β-D-Gal-（1 → 4）-β-D- GlcpNAc-（1 →6）-α-D-Manp-（1 → 6）-β-D-Manp-OMe, was syn- thesized with two approaches. The first approach was a conventional method employing thioglycoside and Koenigs-Knorr glycosylation reaction in 24% overall yield. The second one was a novel route through the azidoiodo-glycosylation strategy by using 2-iodo-2-deoxylactosyl azide as the donor in 36% overall yield.

关 键 词：Antimetastatic tetrasaccharide THIOGLYCOSIDE Koenigs-Knorr method Azidoiodo-glycosylation 2-Iodo-2-deoxyl-actosyl azide β-Methyl mannoside 

分 类 号：O629.1[理学—有机化学]