2型糖尿病患者红细胞胰岛素受体的变化特点及临床意义(附51例报告)  

CHARACTERISTIC AND CLINICAL SIGNIFICANCE OF INSULIN RECEPTORS IN TYPE 2 DIABETES MELLITUS PATIENTS (REPORT OF 51 CASES)

作　　者：周红[1] 张玉华[2] 黄振国[1] 南国珍[1] 

机构地区：[1]河北医科大学第二医院内分泌科,石家庄050000 [2]河北医科大学第二医院同位素科,石家庄050000

出　　处：《河北医科大学学报》2000年第4期205-207,共3页Journal of Hebei Medical University

摘　　要：目的测定 2型糖尿病患者的胰岛功能及红细胞胰岛素受体数目和亲和力。方法采用受体放射分析法测定健康对照组、2型糖尿病肥胖组、非肥胖组的红细胞胰岛素受体 ,用放射免疫法测定胰岛素水平。结果 2型糖尿病肥胖组红细胞胰岛素受体数目显著减少 ,非肥胖组与对照组比较无显著差异 ,3组的亲和常数无显著差异。 2型糖尿病肥胖组、非肥胖组的胰岛素峰值时间较对照组后延 ,且峰值水平显著减低 ,非肥胖组减低更加明显。结论 2型糖尿病患者存在胰岛 β细胞胰岛素分泌反应异常 ,非肥胖组胰岛功能损害更加明显。肥胖组红细胞胰岛素受体数目减少可能是其产生或加强胰岛素抵抗的原因之一。ObjectiveTo observe the pancreatic function ,the numbers and affinity of insulin receptors in erythrocytes in patients with type 2 diabetes mellitus . MethodsInsulin receptors in erythrocytes were studied by receptor radio-analysis in the control group,type 2 diabetes obesity and non-obesity groups. The levels of insulin were detected by radio-immunity in the three groups. ResultsThe numbers of insulin receptors in type 2 diabetes obesity group were significantly decreased compared with non-obesity and the control, there were no difference by comparing type 2 diabetes non- obesity group with the control. The affinity showed no difference among the three groups. The time of insulin peaks in type 2 diabetes obesity or non-obesity groups was delayed and the peaks were lower, the peaks in non-obesity group were significantly decreased especially.ConclusionThe results demonstrated type 2 diabetes obesity or non-obesity all existed pancreatic β cells abnormal insulin reaction, the function of pancreas were injured significantly in type 2 diabetes non-obesity. The reduced numbers of insulin receptors in erythrocytes might be one of the causes in insulin resistance in type 2 diabetes obesity.

关 键 词：糖尿病 NIDDM 胰岛素受体 红细胞 病例报告 

分 类 号：R587.1[医药卫生—内分泌]