大鼠中脑导水管周围灰质内注射抗甲─脑啡肽血清对神经降压素镇痛作用的影响  

ANTI-M-ENKEPHALINE SERUM INJECTED INTO PERIAQUEDUCTAL GRAY WEAKENS ANALGESIC EFFECT OF NEUROTENSIN IN RATS

作　　者：刘玉红[1] 刘文彦[1] 冀强[1] 丁宁 白波[1] 

机构地区：[1]济宁医学院生理学教研室

出　　处：《济宁医学院学报》2000年第2期11-13,共3页Journal of Jining Medical University

基　　金：山东省卫生厅青年基金

摘　　要：目的　探讨大鼠中脑导水管周围灰质内内源性的脑啡肽对神经降压素镇痛作用的影响。方法　采用钾离子透入法以引起大鼠甩尾反应的电流强度为痛反应指标 ,观察中脑导水管周围灰质内注射神经降压素、抗甲 脑啡肽血清对大鼠痛阈的影响。结果　中脑导水管周围灰质内注射神经降压素后 ,大鼠痛阈明显增加 ;注射抗甲 脑啡肽血清后再注射神经降压素 ,大鼠痛阈较注射正常兔血清后再注射神经降压素明显降低 ,但仍高于注射抗甲 脑啡肽血清组。结论　中脑导水管周围灰质内神经降压素在痛觉调制中发挥重要作用 ,其部分效应可能是通过内源性抗甲 脑啡肽中介的。Objective The effect of anti-m-enkephaline serum(AMEKS) injected into periaqueductal gray(PAG) on the pain threshold in rats was investigated in this study.Methods The potassium iontophoresis induced tail-flick was used to measure the pain threshold.Results NT which was injected into PAG produced analgesic effect in the rat.The microinjection of NT in PAG could weaken analgesic effect of AMEKS.Conclusion Our results indicated that NT in PAG may be involved in pain modulation.The effect of NT could be partly effceted by enkephaline.

关 键 词：中脑导水管周围灰质 神经降压素 AMEKS 痛觉调制 

分 类 号：R338.3[医药卫生—人体生理学]