婴幼儿喘息性疾病转归和诱导痰细胞组份EC、IL-5、ECP水平相关性的临床研究  

Infants with asthmatic disease and the clinical study on study on relationship between induced sputum cell components EC IL-5 ECP level

作　　者：彭福梅 胡新菊 白羽 

机构地区：[1]江西省南昌市第三医院新生儿科,330009

出　　处：《中国实用医药》2012年第35期40-42,共3页China Practical Medicine

摘　　要：目的探讨婴幼儿喘息性疾病患者的痰液EC、IL-5、ECP水平,达到早期诊断及早期干预。方法选择2008～2010年收治的1个月至3岁的毛细支气管炎(毛支)、喘息性肺炎(喘肺)112例,分为二组,其中第一次发作毛支、喘肺组84例,发作≥2次组28例,支气管肺炎(无喘息症状)28例为第三组。吸取痰夜1ml进行嗜酸性粒细胞计数(EC),IL-5、ECP检测。结果反复喘息组痰夜EC,IL-5、ECP明显高于其他二组,差异有统计学意义,第一次发作毛支、喘肺组与支气管肺炎组之间差异则无统计学意义;EC、IL-5、ECP之间存在显著正相关;EC、IL-5、ECP水平在同时存在喘息和特应性的患儿最高,在既没有喘息也无个人特应性的患儿最低。结论诱导痰细胞组份EC、IL-5、ECP检测操作简单、无创,且能可靠地预测婴幼儿喘息性疾病的转归,可以在临床上进一步推广使用。Objective Study of infants wheezing disorders in patients with sputum EC IL-5 ECP level,in order to achieve early diagnosis and early intervention.MethodsChoose from 2008 to 2010 were one month to three years with bronchiolitis,asthmatic pneumonia 112 cases,divided into two groups,the first episode of bronchiolitis,asthma lung goup in 84 cases,episode 2 times greater than group 28 cases,bronchial pneumonia 28 cases into third groups.Detection of EC,IL-5 ECP from sputum of 1 ml.ResultsRecurrent wheezing group sputum EC IL-5 ECP were significantly higher than the other two groups,the difference was statistically significant,the first episode of bronchiolitis and bronchial pneumonia group there was no significant difference EC,IL-5 and ECP significant positive correlation exists EC,IL-5 and ECP levels in the simultaneous presence of wheezing and atopic children with the highest,in the absence of wheezing or personal atopic children minimum.ConclusionInduced sputum cell components EC,IL-5 and ECP detection operation is simple,noninvasive,and can reliably predict the outcome in infants with asthmatic diseases,can be clinically popularized further.

关 键 词：婴幼儿 喘息 痰夜 EC IL-5 ECP 

分 类 号：R725.6[医药卫生—儿科]