万古霉素血药浓度与儿科临床疗效关系研究  

Relationship between vancomycin serum concentration and clinical therapeutic in paediatrics

作　　者：游亚兰[1] 贺湘玲[2] 刘文[2] 刘珊珊[2] 邹润英[2] 钱颖翔[2] 邹惠[2] 

机构地区：[1]南华大学,湖南衡阳421001 [2]湖南省人民医院儿科医学中心,湖南长沙410005

出　　处：《吉林医学》2013年第1期26-28,共3页Jilin Medical Journal

摘　　要：目的:分析儿童万古霉素血药浓度与疗效的关系,指导万古霉素在儿童中合理使用。方法:采用回顾性分析使用万古霉素儿童的临床诊断、血药浓度、疗效、不良反应等资料,并进行统计分析。结果:万古霉素常规用量对儿童感染控制有效,但血药浓度偏低,且血药浓度与疗效成正相关;不良反应以转氨酶升高为主,肾毒性较轻。结论:对万古霉素血药浓度监测指导临床个体化用药,提高万古霉素血药浓度以增强疗效,减少药物不良反应。Objective In order to make a conduction of vacomycin clinical usage in paediatrics,the relationship between the therapeutics and serum concentration of vancomycin has been analysed.Method A retrospective survey was applied in the children who took the vancomycin during May.2008 and Feb.2011 in our hospital.Their diagnoses,blood concentration of vacomycin,therapeutics,adverse effect and so on have been recorded and the data was analysed by statistic-software SPSS 16.0.Results It was effective under the present dose.There was a positive correlationship between the blood concentration and therapeutics,but the concentration of vancomycin among children was below the present reference.And the main side effect was the raise of transaminase but the nephrotoxicity was slight.Conclusion An improvement of vancomycin concentration is intensely needed to inhance the therapeutics while the mensuration of concetration is on the way to conduct the the dose of vancomycin individually and reduce the adverse effect.

关 键 词：万古霉素 血药浓度 疗效 不良反应 

分 类 号：R96[医药卫生—药理学]