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作 者:杨啸宇[1] 黎昌强[2] 邱雄[1] 金泽龙[1] 汪平[1] 牟双梦 杨闯[1] 陆小琴[1]
机构地区:[1]雅安职业技术学院附属医院,四川雅安625000 [2]泸州医学院附属医院,四川泸州646000
出 处:《西部医学》2013年第1期35-36,39,共3页Medical Journal of West China
基 金:四川省卫生厅科研课题(090558)
摘 要:目的探索禁食、轮替疗法联合药物治疗食物特异性IgG阳性的慢性荨麻疹的可能机制,为临床治疗提供依据。方法将慢性荨麻疹患者90例分为食物耐受组(A组)30例,采用咪唑斯叮、酮替芬治疗;食物不耐受Ⅰ组(B组)30例,同样采用咪唑斯叮、酮替芬治疗;食物不耐受Ⅱ组(C组)30例,采用咪唑斯叮、酮替芬治疗同时,配合禁食轮替疗法进行治疗;检测3组患者治疗前后食物特异性IgG、组胺及LTB4的水平。结果治疗6个月后,A组和C组组胺水平比治疗前明显降低,B组无明显降低;A组LTB4的水平比治疗前明显降低,B组和C组无明显降低;B组的食物特异性IgG水平无明显变化,C组较治疗前明显降低。结论禁食轮替疗法减少了慢性荨麻疹患者致敏原的摄入,从而减少了对肥大细胞和嗜碱性粒细胞的刺激,减少了组胺的释放,使病情得到了控制。Objective To explore the possible mechanism of fasting and spell combined with antihistamines therapy on the Chronic Urticaria with Food Specific IgG Positive patients, then provide theoretical basis for clinical treatment. Methods 90 patients with Chronic Urticaria were divided into three groups, Group A was 30 cases of chronic urticaria with food specific IgG negative which were treated by mizolastine and ketotifen, Group B was 30 cases of chronic urticaria with food specific IgG positive which were treated the same treatment as A group, Group C was 30 cases of chronic urti- caria with food specific IgG positive which were treated by mizolastine and ketotifen, simultaneously fasting and spell. Detecting the levels of food specific IgG, histamine and LTB-4 of the 3 groups before and after the treatment. Results After 6 months treatment, the histamine level of Group A and C decreased significantly compare with before treatment, while Group B was not; the LTB-4 level of Group A decreased significantly, while Group B and C did not; the levels of food specific IgG of group B had no significant changes, while group C significantly changed. Conclusion The intake of sensibiligen is decreased by fasting and spell treatment, thereby reduce the stimulation on mast cell and basophil for the Chronic Urticaria patients , and the release of the histamine.
关 键 词:禁食 轮替 荨麻疹 食物特异性IGG 组胺 LTB4
分 类 号:R758.24[医药卫生—皮肤病学与性病学]
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