系统性红斑狼疮患者调节性T细胞表型和功能的研究进展  

Advancements of regulatory t cell phenotypes and functions in systemic lupus erythematosus

作　　者：李茗芳[1] 郝飞[1] 

机构地区：[1]第三军医大学西南医院皮肤科,重庆400038

出　　处：《实用医院临床杂志》2013年第1期10-14,共5页Practical Journal of Clinical Medicine

摘　　要：调节性T细胞(Treg)在维持系统性红斑狼疮(SLE)患者自身免疫应答中具有重要的作用。研究发现,尽管在SLE患者中Treg细胞的表型和功能存在定性和/或定量的异常,但不同研究得到的结论却经常相互冲突。造成这一现象的原因可能是由于不同研究选择的患者处在不同的疾病阶段,或者患者疾病活动程度的不同,以及患者是否接受了免疫抑制剂治疗、SLE自身的炎症环境的影响等。在众多研究所提到的Treg细胞标志中,CD25处于高表达水平,并且与转录因子Foxp3并列为SLE中研究最多的两个标志分子。本文将就这两个主要的Treg细胞表型的标记分子的研究进展予以综述。Regulatory T cells（Treg）play a crucial role in maintenance of autoimmune response in systemic lupus erythemato- sus （SLE）. Recently, several studies investigated Treg cell phenotype and function in SLE. Although abnormalities of qualitative and/or quantitative in Treg ceils have been shown, data from different research are con？ ieting sometimes. This phenomenon may be due to dif- ferent stages of the disease the patients were in, under immunosuppressive treatments or inflammatory conditions of SLE patients themselves that might alter Treg cell？ ndings. Among several proposed Treg cell markers, CD25 of high level expression and the transcription factor Foxp3 are the two most popular research hotspots in SLE. In this article, the two major phenotype markers of Treg cell are reviewed.

关 键 词：系统性红斑狼疮 调节性T细胞 CD25 FOXP3 

分 类 号：R751[医药卫生—皮肤病学与性病学] R758.62[医药卫生—临床医学]