血清降钙素原检测在发热性疾病诊断中的意义  

Significance of detection of serum procalcitonin in diagnosis of febrile diseases

作　　者：王晓梅[1] 张建成[1] 周平[1] 董芸[1] 

机构地区：[1]四川省医学科学院.四川省人民医院急诊科,四川成都610072

出　　处：《实用医院临床杂志》2013年第1期80-82,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨血清降钙素原在发热性疾病诊断中的意义。方法检测细菌感染(细菌感染组)、病毒感染(病毒感染组)、系统性红斑狼疮(SLE组)、SLE伴细菌感染(SLE伴细菌感染组)各30例患者及健康体检者(对照组)30例血清降钙素原水平,并测定细菌感染组及SLE伴细菌感染组治疗3天后的血清降钙素原水平。结果细菌感染组及SLE伴感染组的降钙素原水平明显高于病毒感染组、SLE组及对照组,差异均有统计学意义(P<0.05)。病毒感染组、SLE组与对照组之间比较,差异均无统计学意义(P=0.995、P=0.997)。细菌感染组及SLE伴感染组治疗前与治疗体温正常3天后的血清降钙素原水平比较,差异均有统计学意义(P<0.05)。结论降钙素原的检测有助于发热性疾病细菌感染、病毒感染及红斑狼疮伴细菌感染的诊断。Objective To investigate the diagnostic significance of serum procalcitonin in patients with febrile diseases. Methods One hundred and fifty patients were involved in the study. These patients included 30 patients with bacterial infection,30 with virus infection ,30 with systemic lupus erythematosus（SLE） ,30 SLE with bacterial infection and 30 healthy controls. The levels of serum procalcitonin were measured before and after treatment. Results The serum procalcitonin levels in patients with bacterial infection and SLE patients with bacterial infection were significantly higher than that of patients with viral infection, SLE alone or healthy controls （P =0. 000 ）, but no significant difference was found among patients with virus infection, SLE alone and healthy controls. The serum procalcitonin levels were significantly decreased after 3 days when body temperature of patients with bacterial infection or SLE patients with bacterial infection returned to normal（P = 0. 000）. Conclusions The detection of serum procalcitonin level may be used for the differentiate diagnosis of bacterial infection,virus infection or SLE with bacterial infection.

关 键 词：降钙素原 发热性疾病 诊断 

分 类 号：R593.24[医药卫生—内科学] R511[医药卫生—临床医学]