内源性下行抑制/易化系统与5-羟色胺对脊髓伤害感受性信息的调制  

Endogenous Descending Inhibitory/Facilitatory System and Serotonin (5-HT) Modulating Spinal Nociceptive Transmission

作　　者：张玉秋[1] 吴根诚[1] 

机构地区：[1]上海医科大学医学神经生物学国家重点实验室

出　　处：《生理科学进展》2000年第3期211-216,共6页Progress in Physiological Sciences

基　　金：中国博士后科学基金! (第 2 4期 );国家自然科学基金! (39970 92 5)资助课题

摘　　要：内源性下行抑制系统在痛觉传递与调制中具有重要作用。近年来 ,与这一系统相对的下行易化系统开始引起人们的关注。中枢神经系统通过下行抑制 /易化系统对外周伤害性信息进行双向调制。 5 羟色胺 ( 5 HT)是痛觉下行调制系统的主要神经递质 ,电刺激或微量注射兴奋性氨基酸于中缝大核 (NRM )或巨细胞网状核(NGC)内 ,既可兴奋也可抑制脊髓伤害性反应。这种相互矛盾的效应可能与脊髓内的多种 5 HT受体亚型有关。Endogenous descending inhibitory system plays an important role in the modulation of nociceptive transmission. In recent years, descending facilitatory system has been noted. CNS bi directionally modulates the peripheral nociceptive transmission at the spinal cord level via the descending inhibitory/facilitatory system. Serotonin (5 HT) is the main neurotransmitter in descending pain modulation. Intrathecal application of 5 HT or electrical stimulation or glutamate microinjection into the nucleus raphe magnus (NRM) and nucleus reticularis gigantocellularis(NGC) may produce inhibition and / or facilitation of spinal nociceptive transmission. The contradictory results may be attributed to the nonselective action(s) of 5 HT at multiple subtypes of 5 HT receptor in spinal cord.

关 键 词：下行抑制 下行易化 5-HT受体 痛觉传递 痛觉调制 

分 类 号：Q426[生物学—神经生物学] R338[生物学—生理学]