卡介菌多糖核酸治疗春季结膜炎的疗效及对外周血T淋巴细胞亚群的影响研究  

Clinical efficacy of BCG polysaccharide nucleic acid in treatment of vernal conjunctivitis and influence on peripheral blood T cell subsets

作　　者：孙昊[1] 

机构地区：[1]淮安市第二人民医院眼科,江苏淮安223001

出　　处：《中华医院感染学杂志》2013年第1期13-14,26,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨研究卡介菌多糖核酸(BCG-PSN)治疗春季结膜炎的疗效,评价BCG-PSN治疗春季结膜炎的临床疗效;同时观察对外周血T淋巴细胞亚群的影响。方法选择医院2009年1月-2010年11月收治的64例典型春季结膜炎患者,随机平均分为两组,对照组给予常规治疗,研究组在常规治疗的基础上给予肌内注射BCG-PSN治疗,对比两组的临床疗效,同时观察外周血T淋巴细胞亚群的变化情况。结果研究组治疗的总有效率为96.87%,显著高于对照组的71.87%(P<0.05);治疗后研究组CD4+、CD4+/CD8+比值较治疗前明显升高(P<0.05),CD8+较治疗前明显降低(P<0.05);对照组CD4+、CD8+、CD4+/CD8+比值较治疗前无显著变化。结论 BCG-PSN治疗春季结膜炎的临床疗效确切,且能有效地协调CD4+、CD8+T淋巴细胞的动态平衡,值得临床广泛推广。OBJECTIVE To study and evaluate the clinical efficacy of BCG polysaccharide nucleic acid （BCG-PSN） in treatment of vernal conjunctivitis （VKC） and observe the influence on the peripheral blood T cell susets. METHODS A total of 64 cases of patients with VKC who enrolled the hospital from Jan 2009 to Oct 2010 were selected and divided into two groups. The control group was treated by the routine treatment, while the study group was treated by BCG-PSN injections based on the routine treatment. The clinical efficacy of the two groups was compared,and the change of the peripheral blood T cell subsets was observed. RESULTS The total effective rate of the study group was 96.87%1 significantly higher than 71.87% of the control group （P〈0.05）. The CD4^＋ and CD4^＋/ CD8^＋ levels was elevated higher after the treatment than before the treatment, but the CD8^＋ level was significantly decreased as compared with that before the treatment （P〈0.05）. There was no significant change in the CD4^＋, CD8^＋ , and CD4^＋/CD8^＋ levels in the control group between before and after the treatment. CONCLUSION BCG-PSN is with definite clinical efficacy in treatment of vernal conjunctivitis. It can effectively coordinate the dynamic balance of CD4^＋ and CD8^＋ levels and is worthy of the clinical promotion.

关 键 词：卡介菌多糖核酸 结膜炎 T淋巴细胞亚群 疗效 

分 类 号：R181.32[医药卫生—流行病学]