甲状腺手术围术期使用抗菌药物的干预研究  

Case control study on interventions to application of antibiotics during perioperative period of thyroid surgery

作　　者：阮燕萍[1] 俞洋[1] 余元明[1] 

机构地区：[1]浙江省肿瘤医院院感科,浙江杭州310022

出　　处：《中华医院感染学杂志》2013年第1期157-159,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨清洁手术围术期抗菌药物合理应用的有效干预措施。方法调查某院2011年4月和10月出院的228例甲状腺清洁手术患者抗菌药物使用情况,其中4月94例为干预前组,10月134例为干预后组;其间采取的干预措施包括教育性干预、行政性干预和限制性干预。结果干预后抗菌药物使用率从100.00%下降至3.73%;使用强度从64.05DDD下降至0.31DDD;用药品种由6种下降至1种,抗菌药物选择趋于相对合理;人均使用抗菌药物金额从64.27元下降至4.00元;手术部位感染率无增加;且两组病例在住院时间、术后住院天数及术后使用抗菌药物时间差异无统计学意义。结论该院实施的综合性干预措施有效可行,为清洁手术围术期抗菌药物的合理使用提供了有益的管理经验。OBJECTIVE To explore the effective intervention measures for the rational application of antibiotics during the perioperative period of the clean surgery. METHODS The application of antibiotics of 228 patients who underwent the thyroid clean operation and discharged from hospital in Apr and Oct of 2011 was investigated, the 94 cases in Apr were set as the pre-intervention group, 134 cases in Oct wereet as the post-intervention group. The intervention measures including the educational intervention, administrative intervention, and restrictive intervention were adopted during the surgery process. RESULTS The utilization rate of antibiotics after the interventions decreased from 100.00% to 3.73%, the use intensity decreased from 64.05DDD to 0.31DDD, the antibiotic varieties decreased from 6 to 1, the choice of antibiotics tended to be relatively reasonable The average cost of antibiotics decreased from 64.27 yuan to 4.00 yuan, and the incidence of the surgical site infections was not increased. The differences in the hospital stay, postoperative hospitalization duration, and the duration of postoperative use of antibiotics between the two groups were not statistically significant. CONCLUSION The comprehensive intervention measures are feasible and effective, which have provided useful management experience on rational application of antibiotics during the perioperative period of the clean surgery.

关 键 词：甲状腺 抗菌药物 病例对照研究 

分 类 号：R978.1[医药卫生—药品]