东莞地区流动人口女性HPV感染危险因素调查及治疗效果  

Investigation on risk factors of HPV infection in floating women in Dongguan city and curative effect

作　　者：韩临晓[1] 刘燕燕[1] 袁秀英[1] 孙晓岩[1] 

机构地区：[1]广东省东莞市石龙人民医院妇科,523326

出　　处：《中国妇幼保健》2013年第1期82-85,共4页Maternal and Child Health Care of China

基　　金：2010年广东省科研基金支持立项〔2010B031900001031〕

摘　　要：目的:了解东莞地区流动女性人乳头瘤病毒(HPV)的感染情况及其危险因素并探讨中药治疗宫颈HPV感染的疗效。方法:对3142名流动育龄女性进行保密式问卷调查并采用HCⅡ法进行HPV分型检测,同时进行液基细胞学检查(TCT);将304名高危HPV感染阳性患者分为中药组95例、α干扰素治疗组95例、对照组94例,治疗1～3个疗程复查HPV转阴情况。结果:高危型HPV感染率为9.7%。初中及以下文化程度、结婚年龄≤20岁、分娩年龄≤20岁、性生活频率每周3次及以上的女性HPV感染率明显升高;患者治疗1～3个疗程后中药组和α干扰素组转阴率明显高于对照组,且治疗3个疗程后中药组转阴率明显高于α干扰素组。结论:文化程度低、早婚早育、性生活过频是宫颈HPV感染的危险因素,中药可有效治疗宫颈HPV感染,预防宫颈癌的发生。Objective： To understand the infectious status and risk factors of human papillomavirus （HPV） in floating women in Dongguan city, and explore the curative effect of traditional Chinese medicine for treatment of cervical HPV infection. Methods： A total of 3 142 floating women of childbearing age were surveyed by a confidential questionnaire, and HC Ⅱ method was used for HPV classification and detection, liquid - based thin - layer cytologic test was performed during the same period; 304 patients with high risk HPV infection were di- vided into traditional Chinese medicine group （95 patients）, α -interferon treatment group （95 patients ）, and control group （94 patients）, the negative conversion rates of HPV were reexamined after 1 - 3 courses of treatment in the three groups. Results： The infection rate of high - risk HPV was 9. 7%. The infection rates were significant higher among the women who had educational level of junior high school or below, marriage age ≤20 years, delivery age ≤20 years, the frequency of sexual life 3 times per week or more. After 1 - 3 courses of treat- ment, the negative conversion rates in traditional Chinese medicine group and ct - interferon treatment group were significantly higher than those in control group, and after 3 courses of treatment, the negative conversion rate in traditional Chinese medicine group was significantly higher than that in α - interferon treatment group. Conclusion： Low educational level, early marriage or early childbearing, and too frequent sexual life were risk factors of cervical HPV infection. Traditional Chinese medicine can treat cervical HPV infection effectively and prevent cervical cancer.

关 键 词：流动人口 宫颈人乳头瘤病毒感染 危险因素 中药 

分 类 号：R173[医药卫生—妇幼卫生保健]