拉曼光谱法检测拉米夫定晶型Ⅰ  

Determination of Lamivudine Monomorphic Form I by Raman Spectroscopy

作　　者：叶晓霞[1] 刘茜[1] 耿志旺[1] 杨永健[1] 

机构地区：[1]上海市食品药品检验所,上海201203

出　　处：《中国医药工业杂志》2013年第1期60-63,共4页Chinese Journal of Pharmaceuticals

摘　　要：以红外光谱、X射线粉末衍射和拉曼光谱表征拉米夫定的晶型I和晶型II。选用拉曼光谱分析技术,以拉米夫定晶型I的特征峰(697 cm-1)与内标峰(537 cm-1)的强度比为定量参数,测定拉米夫定中晶型I的含量。拉米夫定晶型I的特征峰与内标峰的强度比在晶型I浓度0～100%范围内线性关系良好,最低检测限为1.2%,最低定量限为3.7%。Lamivudine form I and form Ⅱ were charactered by FT-IR, XRD and Raman spectroscopy. Aquantitative method for the determination of monomorphic form Ⅰ using Raman spectroscopy was established by Raman intensity ratio of the specific peak（697 cm^-1） and the reference peak（537 cm^-1）. The calibration curve was linear in the concentration range of form Ⅰ of 0 - 100%. The LLOD was 1.2% and LLOQ was 3.7%.

关 键 词：拉曼光谱法 拉米夫定 多晶型 

分 类 号：O657.37[理学—分析化学]