1,5-二芳基-1,4-戊二烯-3-酮衍生物的合成及其荧光光谱研究  

Synthesis and fluorescence spectroscopy of 1,5-diarylpenta-1,4-dien-3-one

作　　者：杨金诚[1] 钟浩[1] 刘利军[1] 

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021

出　　处：《化学试剂》2013年第1期17-20,73,共5页Chemical Reagents

摘　　要：以取代苯甲醛和丙酮为原料,改进文献合成方法,采用一锅法合成了5个对称和5个不对称取代双苄叉丙酮化合物,通过红外光谱、核磁共振谱、质谱对其进行了结构表征,利用分子荧光光谱法研究了该类化合物与人血清蛋白的相互作用,并测定了对蛋白猝灭效果较好的二对二甲氨基双苄叉丙酮的猝灭常数。5 Symmetric and 5 asymmetric substituted dibenzylidene acetones were synthesized from a variety of sub- stituted benzaldehyde and acetone in one step. The structures were characterized by IR, MS, NMR. The interactions between the 10 compounds and human serum albumin （HSA） were also studied using fluorescence spectroscopy. The quenching constant of 1,5-bis-（ 4＇-N, N-dimethylamino phenyl） penta- l E ,4E-dien-3-one was measured. 1,5-bis- （ 4＇-N, N-dimethyl- amino phenyl ） penta-lE, 4E-dien-3-one showed the best quenching effect with HSA.

关 键 词：Claisen-Schmidt缩合 合成 人血清蛋白 荧光光谱 

分 类 号：O621.3[理学—有机化学]