鼻咽癌药物疗法的药效分析  

Efficacy analysis of nasopharyngeal cancer drug therapy

作　　者：区通源[1] 潘智灵[1] 

机构地区：[1]广东药学院附属第一医院,广州510080

出　　处：《西北药学杂志》2013年第1期82-84,共3页Northwest Pharmaceutical Journal

摘　　要：目的从治疗效果、安全性、经济合理性角度探讨治疗中晚期鼻咽癌患者的不同用药方案,选出最佳用药方案。方法统计2000年至2005年共173例中晚期鼻咽癌患者不同治疗方案的治疗效果(有效率、2年复发率和5年存活率),药物不良反应,药物成本,并联系近期研究数据进行分析比较。其中紫杉醇+顺铂治疗组(PP组)41例,环磷酰胺+5-FU治疗组(CF组)32例,顺铂+5-FU治疗组(PF组)33例,平阳霉素+5-FU(BF组)治疗组30例,阿霉素+顺铂治疗组(AP组)37例。结果 PP组的有效率高达78%,2年复发率为31%,5年存活率为68%,其不良反应主要为骨髓抑制、神经毒性等,其程度较轻,但药物成本高。其余各组的治疗效果各有特点,有不同类型以及不同程度的不良反应,各组的药物成本也各不相同。结论综合治疗效果、安全性、经济合理性这3个因素考虑,顺铂+5-FU方案以其有效率较高、毒性小、不良反应较轻,而且药物成本经济合理,在研究的5组方案中是最佳方案。Objective To analyze the effects of treatment,safety,and economic rationality,to explore the treatment regimen for patients with advanced nasopharyngeal carcinoma,and to select the best regimen.Methods The therapeutic effect of the statistics from 2000 to 2005,a total of 173 cases of patients with advanced nasopharyngeal carcinoma of different treatment programs（efficiency,2-year recurrence rate and 5-year survival rate）,adverse drug reactions,drug costs,and contact the recent research data were analyzed and compared,in which paclitaxel alcohol cisplatin treatment group（PP group） 41 cases,cyclophosphamide,5-FU treatment group（CF） 32 cases,cisplatin 5-FU treatment group（PF group） 33 cases,BLM,5-FU（BF） treatment group 30 cases,doxorubicin cisplatin treatment group（AP group） 37 cases.Results The PP group was up to 78% efficiency,the 2-year recurrence rate 31%,the 5-year survival 68%.The main side effects were myelosuppression,and neurotoxicity.The rest group had their own characteristics,different types and different degrees of adverse reactions.Each group of drug costs also varied.Conclusion The effect of integrated treatment,security,economic rationality,had to be considered.Cisplatin and 5-FU,for its higher efficiency lighter cytotoxicity,lower costs is recommended.

关 键 词：顺铂 紫杉醇 鼻咽癌 有效率 药效分析 

分 类 号：R979.1[医药卫生—药品]