非甾体抗炎药物对结直肠吻合口愈合影响的研究进展  

Research progress of the nonsteroidal anti-inflammatory drugs on colorectal anastomotic healing

作　　者：嵇承栋[1] 熊源长[2] 

机构地区：[1]同济大学附属杨浦医院 上海市杨浦区中心医院麻醉科,200090 [2]第二军医大学附属长海医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2013年第1期62-65,共4页International Journal of Anesthesiology and Resuscitation

基　　金：基金项目：上海市卫生局科研计划基金资助项目（2012088）

摘　　要：背景非甾体抗炎药物（non-steroidal anti-inflammatory drugs，NSAIDs）是一类具有抗炎、镇痛和解热等作用的药物，其主要通过抑制环氧化物酶阻断花生四烯酸合成前列腺素而发挥解热、镇痛、抗炎作用。近年来，NSAIDs与麻醉药品并用于围手术期镇痛取得了良好的临床效果，尤其被广泛应用于手术后镇痛。目的吻合口漏是结直肠外科最严重的并发症之一，NSAIDs是否影响结直肠吻合口的愈合、增加吻合口漏的发生率文献报道不一。内容总结近年来关于NSAIDs对人体及实验动物结直肠吻合口愈合影响的代表性文献。趋向为手术后合理、安全使用NSAIDs提供参考，并总结NSAIDs对结直肠吻合口愈合影响的可能的机制。Background Non-steroidal anti-inflammatory drugs （NSAIDs） are a class of drugs with effects of antiinflammatory, analgesic and antipyretic.It is main by the way of blocking arachidonic acid synthesis of prostaglandins by inhibiting epoxide hydrolase to achieve the effects of antipyretic, analgesic and anti-inflammatory. In recent years, use of NSAIDS with narcotic drugs for perioperative analgesia achieved good clinical result,it particularly widely used in post-operative analgesia. Objective Anastomotic leakage is one of the most serious complications in colorectal surgery.The reports about whether NSAIDs affect colorectal anastomotic healing and increase the incidence of anastomotic leak are different. Content This review summarizes representative literature NSAIDs colorectal anastomotic healing in humans and experimental animals in recent years. Trend This review provides a reference for the safe use of NSAIDs and summarizs the impact of NSAIDs on colorectal anastomotic healing mechanism.

关 键 词：非甾体抗炎药物 结直肠 吻合口 吻合口漏 愈合 

分 类 号：R6[医药卫生—外科学]