心肌缺血／再灌注损伤中细胞胀亡产生机制的研究进展  

The role of oneosis in mycardial ischemia/reperfusion injury

作　　者：姜秀丽[1,2] 宋杰[2] 王琛[1] 

机构地区：[1]苏州大学附属第二医院麻醉科,215004 [2]南通市第一人民医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2013年第1期77-80,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景细胞胀亡和凋亡均可出现在心肌缺血，再灌注损伤（ischemia／reperfusion injury，I／RI）过程中。胀亡是一种特殊形式的非凋亡性细胞死亡方式，它的特征表现为细胞肿胀、起泡、细胞器肿胀、细胞膜通透性增加和核溶解。目的明确细胞胀亡在心肌缺血／再灌注（ischemia／reperfusion，I／R）发生、发展中的作用将有助于心肌保护研究的深入。内容阐述细胞胀亡的生物学特性、发生机制及与心肌I／RI。趋向通过对心肌I／RI中细胞胀亡的深入了解和研究，有可能带来心肌保护的新突破。Background Onconsis and apoptosis may occur in mycardial ischemia/reperfusion injury （I/RI）. Onconsis is a special model of non-apoptotic cell death. It is characterized by cell swelling, blistering, organelles swelling, cell membrane permeability and caryolysis. Objective Understanding the role of oncosis occurs in myocardial ischemia/reperfusion（I/R） may help us understand the myocardial protection research. Content The role of oneosis in the biological characteristics mechanism and in myocardial I/RI were reviewed in this article. Trend New breakthrough in myocardial protection may be found by understanding myocardial cell oncosis.

关 键 词：胀亡 凋亡 心肌再灌注损伤 

分 类 号：R54[医药卫生—心血管疾病]