麻醉药对发育期大脑毒性作用的研究进展  

Review on studies of anesthetics toxicity to the developing brain

作　　者：陈玢[1] 郑晖[1] 

机构地区：[1]北京市结核病胸部肿瘤研究所 首都医科大学附属北京胸科医院麻醉科,101149

出　　处：《国际麻醉学与复苏杂志》2013年第1期85-88,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景麻醉药广泛应用于各种手术的临床麻醉，其神经毒性一直是麻醉学领域的研究热点。越来越多的证据使麻醉学领域开始质疑麻醉药对于发育期婴幼儿的安全。目的研究麻醉药和神经毒性之间的关系，从而在临床中采取必要措施来避免麻醉药对于大脑的神经毒性。内容回顾麻醉药对于发育期大脑的影响，总结导致神经毒性的可能机制，并对近年来的实验和临床研究进行分析。趋向由于前瞻陛随机临床试验的操作难度大，因此很难在短期内对麻醉药和神经毒性关系的临床研究取得实质性进展。Background Anesthetics have been widely used in clinical anesthesia for a wide range of surgeries. The neurotoxicity of anesthetics has been a research hotspot in anesthesiology. Accumulating evidence is forcing the anesthesia community to question the safety of anesthetics to the developing brain. Objective It is important to study the relationship between anesthetics and neurotoxicity in order to take necessary measures to counter the neurotoxicity by using anesthetics. Content To review the effects of anesthetics to the developing brains and summarize the possible mechanisms of anesthetics and neurotoxicity. Meanwhile, to analyze the experimental and clinical data in recent years. Trend Due to the difficulty in designing and executing prospective randomized clinical trials, it is unlikely to make substantial progress on the clinical studies of the relationship between anesthetics and neurotoxicity in the near future.

关 键 词：麻醉药 发育期大脑 神经毒性 

分 类 号：R614[医药卫生—麻醉学]