还原型谷胱甘肽对风心病瓣膜置换患者的心肌保护作用  

Myocardial Protection Effect of Reduced Glutathione in Rheumatic Heart Diseases with Valve Replacement

作　　者：杨彬[1] 刘锋[2] 熊卫民[1] 黄标通[1] 龙建平[1] 

机构地区：[1]解放军第163医院胸心外科,湖南长沙410003 [2]中南大学湘雅二医院胸心外科,湖南长沙410011

出　　处：《医学临床研究》2012年第12期2278-2280,共3页Journal of Clinical Research

摘　　要：[目的]探讨还原型谷胱甘肽（GSH）加入心脏停搏液对风湿性心脏病瓣膜置换术患者的心肌保护作用。[方法]30例择期行心脏瓣膜置换术的风心病患者随机分为GSH组及对照组（C组）各15例。GsH组在含血停搏液中加入GSH（1500mg／m2）进行心脏灌注，C组不加GSH。检测两组心肌酶、高敏肌钙蛋白T（hs—TNT）、丙二醛（MDA）浓度及氨基末端脑钠肽前体（NT-proBNP）水平变化。[结果]两组患者主动脉开放后心肌酶、hs—TNT、MDA及NT—proBNP水平较麻醉诱导后升高，且GSH组升高低于C组。[结论IGSH对风湿性心脏病患者具有良好的心肌保护作用。[Objective] To explore the myocardial protection effect of reduced glutathione（GSH） in rheumatic heart diseases with valve replacement. [Methods] Thirty patients undergoing cardiac valve replacement were randomly divided into reduced glutathione group（group GSH, n = 15） and control group（group C）. GSH 1500mg/m2 was added into cardioplegia solution for heart perfusion of group GSH. Group C did not receive GSH. The changes of myocardial enzymes, high sensitive troponin（hs-TNT）, malondialdehyde（MDA） and NT-proBNP in two groups were determined. [Results] Compared with after anesthesia induction, the levels of myocardial enzymes, hs-TNT, MDA and NT-proBNP in two groups after opening the aorta increased. The increasing of myocardial enzymes, hs-TNT, MDA and NT-proBNP in GSH group was lower than that in group C. [Conclusion] GSH is effective for myocardial protection in patients with rheumatic heart diseases.

关 键 词：风湿性心脏病 药物疗法 心脏瓣膜 人工 谷胱甘肽 药理学 

分 类 号：R654.1[医药卫生—外科学]