心脏储备功能指标评估慢性心力衰竭严重程度的研究  

A study on evaluation of severity degrees of chronic heart failure by cardiac functional reserve indicators

作　　者：吴晓军[1] 秦俭[1] 郭兴明[2] 卢德林[2] 肖守中[3] 肖子夫[3] 

机构地区：[1]重庆医科大学附属第一医院心内科,重庆400016 [2]重庆大学生物工程学院重庆市医疗电子工程技术研究中心,重庆400030 [3]博精医学与信息工程研究所,重庆400044

出　　处：《重庆医学》2013年第2期143-145,148,共4页Chongqing medicine

摘　　要：目的探讨心脏储备功能指标对慢性心力衰竭(CHF)的评估价值。方法将136例CHF患者作为心衰组,46例健康者作为对照组。采用彩色多普勒超声心动图检查,计算左心室射血分数(LVEF);进行6min步行试验(6MWT),采用心脏储备无创监测系统检测舒张期时限与收缩期时限比值(D/S),评价LVEF、6MWT及D/S值与心功能状态的相关性。结果心衰组患者的6MWD、D/S值、LVEF明显低于对照组(P<0.05);采用双变量Pearson相关系数法分析显示,D/S值、6WMD与纽约心脏协会(NYHA)心功能分级呈显著负相关(r=-0.659,P<0.01;r=-0.561,P<0.01);LVEF与NYHA心功能分级呈正相关(r=0.203,P<0.05)。结论 D/S值能较好反映CHF患者的心功能状态,可作为评估心功能的一个新型有效指标。Abstract：Objective To explore value of functional cardiac reserve indicators in evaluation chronic heart failure（CHF）. Methods 136 patients with CHF served as heart failure group and 46 healthy people as control group. Color Doppler ultrasound echocardio graphy was used and left ventricular ejection fraction（LVEF） were calculated. 6 minute walk test（6MWT） was performed, and car diac reserve non-invasive monitoring system was employed to detect ratios of diastolic phase duration to systolic phase duration（D/ S）. The correlations between LVEF, 6MWT, D/S value and cardiac functional status were evaluated, respectively. Results 6MWD, D/S value and LVEF of patients in heart failure group were obviously lower than those in control group（P〈0.05）. Ac cording to bivariate Pearson correlation coefficient analysis, D/S value and 6WMD showed negative correlation with New York heart assoeiation（NYHA） cardiac functional grading（r= -0. 659, P〈0.01;r= -0. 561,P〈0.01）. LVEF and NYHA cardiac functional grading were positively correlated （r= 0. 203, P〈0.05）. Conclusion D/S value reflects well on status of cardiac function of patients with CHF, and can he served as a new and effective indicator in evaluation of cardiac function.

关 键 词：心力衰竭 充血性 评价研究 舒张期时限与收缩期时限比值 左心室射血分数 6 MIN步行试验 

分 类 号：R541.6[医药卫生—心血管疾病]